[Mutagenic effect of mitomycin C on different strains of oleandomycin producer Streptomyces antibioticus]. / Mutagennoe deistvie mitomitsina C na raznye shtammy produtsenta oleandomitsina Streptomyces antibioticus.
Antibiot Khimioter
; 34(11): 811-3, 1989 Nov.
Article
en Ru
| MEDLINE
| ID: mdl-2517387
Mitomycin C, a DNA-tropic antibiotic, was shown to have a lethal effect on spore sprouts of two strains of Streptomyces antibioticus, an organism producing oleandomycin. When the time of exposure to the antibiotic increased there was an almost equal decrease in the survival rate. The mutagen action on the morphological variation and antibiotic production of the two closely related strains were diverse due to their genetic differences. The strain isolated after the culture treatment with a chemical mutagen and subjected to a more prolonged maintaining selection showed lower variation with respect to its colony morphology. The other strain isolated after treatment of the culture with high concentrations of its own antibiotic showed lower variation with respect to its antibiotic production property. The shift in the antibiotic production in the direction of the low active variants was characteristic of the both highly productive strains.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Streptomyces
/
Streptomyces antibioticus
/
Mitomicinas
/
Mutación
Idioma:
Ru
Revista:
Antibiot Khimioter
Asunto de la revista:
TERAPIA POR MEDICAMENTOS
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Rusia