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Effect of Flos carthami Extract and α 1-Adrenergic Antagonists on the Porcine Proximal Ureteral Peristalsis.
Wu, San-Yuan; Man, Kee-Ming; Shen, Jui-Lung; Chen, Huey-Yi; Chang, Chiao-Hui; Tsai, Fuu-Jen; Hsieh, Wen-Tsong; Winardi, Daniel; Lee, Yuan-Ju; Tsai, Kao-Sung; Lin, Yu-Ning; Chen, Yung-Hsiang; Chen, Wen-Chi.
Afiliación
  • Wu SY; Department of Anesthesiology, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan ; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University,
  • Man KM; Department of Anesthesiology, Tungs' Taichung MetroHarbor Hospital, Taichung 435, Taiwan ; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University,
  • Shen JL; Department of Dermatology, Taichung Veterans General Hospital, Taichung 407, Taiwan.
  • Chen HY; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Departments of Obstetrics and Gynecology, Medical Genetics and Pedi
  • Chang CH; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan.
  • Tsai FJ; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Departments of Obstetrics and Gynecology, Medical Genetics and Pedi
  • Hsieh WT; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan.
  • Winardi D; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan.
  • Lee YJ; Department of Urology, National Taiwan University Hospital, Taipei 100, Taiwan.
  • Tsai KS; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Departments of Obstetrics and Gynecology, Medical Genetics and Pedi
  • Lin YN; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan.
  • Chen YH; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Departments of Obstetrics and Gynecology, Medical Genetics and Pedi
  • Chen WC; Graduate Institute of Integrated Medicine, Institute of Chinese Medicine, School of Chinese Medicine, Department of Pharmacology, Research Center for Chinese Medicine and Acupuncture, China Medical University, Taichung 404, Taiwan ; Departments of Obstetrics and Gynecology, Medical Genetics and Pedi
Evid Based Complement Alternat Med ; 2014: 437803, 2014.
Article en En | MEDLINE | ID: mdl-25170340
Traditional Chinese medicine (TCM) has been proposed to prevent urolithiasis. In China, Flos carthami (FC, also known as Carthamus tinctorius) (Safflower; Chinese name: Hong Hua/) has been used to treat urological diseases for centuries. We previously performed a screening and confirmed the in vivo antilithic effect of FC extract. Here, ex vivo organ bath experiment was further performed to study the effect of FC extract on the inhibition of phenylepinephrine (PE) (10(-4) and 10(-3) M) ureteral peristalsis of porcine ureters with several α 1-adrenergic antagonists (doxazosin, tamsulosin, and terazosin) as experimental controls. The results showed that doxazosin, tamsulosin, and terazosin dose (approximately 4.5 × 10(-6) - 4.5 × 10(-1) µg/mL) dependently inhibited both 10(-4) and 10(-3) M PE-induced ureteral peristalsis. FC extract achieved 6.2% ± 10.1%, 21.8% ± 6.8%, and 24.0% ± 5.6% inhibitions of 10(-4) M PE-induced peristalsis at doses of 5 × 10(3), 1 × 10(4), and 2 × 10(4) µg/mL, respectively, since FC extract was unable to completely inhibit PE-induced ureteral peristalsis, suggesting the antilithic effect of FC extract is related to mechanisms other than modulation of ureteral peristalsis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Evid Based Complement Alternat Med Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos