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Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice.
Antsiferova, Olga; Müller, Anne; Rämer, Patrick C; Chijioke, Obinna; Chatterjee, Bithi; Raykova, Ana; Planas, Raquel; Sospedra, Mireia; Shumilov, Anatoliy; Tsai, Ming-Han; Delecluse, Henri-Jacques; Münz, Christian.
Afiliación
  • Antsiferova O; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
  • Müller A; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
  • Rämer PC; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
  • Chijioke O; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
  • Chatterjee B; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
  • Raykova A; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
  • Planas R; Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zürich, Zürich, Switzerland.
  • Sospedra M; Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University Hospital Zürich, Zürich, Switzerland.
  • Shumilov A; Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
  • Tsai MH; Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
  • Delecluse HJ; Division of Pathogenesis of Virus Associated Tumors, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
  • Münz C; Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
PLoS Pathog ; 10(8): e1004333, 2014 Aug.
Article en En | MEDLINE | ID: mdl-25165855
Epstein Barr virus (EBV) infection expands CD8+ T cells specific for lytic antigens to high frequencies during symptomatic primary infection, and maintains these at significant numbers during persistence. Despite this, the protective function of these lytic EBV antigen-specific cytotoxic CD8+ T cells remains unclear. Here we demonstrate that lytic EBV replication does not significantly contribute to virus-induced B cell proliferation in vitro and in vivo in a mouse model with reconstituted human immune system components (huNSG mice). However, we report a trend to reduction of EBV-induced lymphoproliferation outside of lymphoid organs upon diminished lytic replication. Moreover, we could demonstrate that CD8+ T cells against the lytic EBV antigen BMLF1 can eliminate lytically replicating EBV-transformed B cells from lymphoblastoid cell lines (LCLs) and in vivo, thereby transiently controlling high viremia after adoptive transfer into EBV infected huNSG mice. These findings suggest a protective function for lytic EBV antigen-specific CD8+ T cells against EBV infection and against virus-associated tumors in extra-lymphoid organs. These specificities should be explored for EBV-specific vaccine development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T Citotóxicos / Transformación Celular Viral / Infecciones por Virus de Epstein-Barr Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS Pathog Año: 2014 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Linfocitos T Citotóxicos / Transformación Celular Viral / Infecciones por Virus de Epstein-Barr Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS Pathog Año: 2014 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos