Application of chemometric techniques in search of clinically applicable biomarkers of disease.
Drug Dev Res
; 75(5): 283-90, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-25160068
Metabolomics deals with the global assessment of the metabolites present in a biological system to evaluate the progress of the disease, select potential biomarkers, and provide insights into the underlying pathophysiology. As metabolomic analysis generates large quantities of data, multivariate data analysis techniques and chemometrics are often used to interpret experimental results. The present overreview describes various chemometric methods that are frequently used in clinical biomarker studies, with emphasis on data analysis strategies and validation of classification and prognostic models. Moreover, an overview of most interesting recent biomarker discovery publications is provided to highlight the clinical applications of chemometric techniques used for bioanalytical data interpretation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Metabolómica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Drug Dev Res
Año:
2014
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Estados Unidos