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Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function.
Kovács, Katalin Réka; Bajkó, Zoltán; Szekeres, Csilla Cecília; Csapó, Krisztina; Oláh, László; Magyar, Mária Tünde; Molnár, Sándor; Czuriga, Dániel; Kardos, László; Burainé, Andrea Bojtor; Bereczki, Dániel; Soltész, Pál; Csiba, László.
Afiliación
  • Kovács KR; Department of Neurology, Clinical Center, University of Debrecen, Debrecen, Hungary. Electronic address: kovacskatireka@yahoo.com.
  • Bajkó Z; Department of Neurology, Mures County Clinical Emergency Hospital, Târgu-Mures, Romania.
  • Szekeres CC; Department of Neurology, Elisabeth Teaching Hospital of Sopron, Sopron, Hungary.
  • Csapó K; Department of Neurology, Clinical Center, University of Debrecen, Debrecen, Hungary.
  • Oláh L; Department of Neurology, Clinical Center, University of Debrecen, Debrecen, Hungary.
  • Magyar MT; Department of Neurology, Clinical Center, University of Debrecen, Debrecen, Hungary.
  • Molnár S; Department of Neurology, Elisabeth Teaching Hospital of Sopron, Sopron, Hungary.
  • Czuriga D; Institute of Cardiology, Clinical Center, University of Debrecen, Debrecen, Hungary.
  • Kardos L; Contract Medical Statistician, Kenézy Gyula Hospital, Debrecen, Hungary.
  • Burainé AB; Department of Neurology, Clinical Center, University of Debrecen, Debrecen, Hungary.
  • Bereczki D; Department of Neurology, Semmelweis University, Budapest, Hungary.
  • Soltész P; Department of Angiology, Medical Faculty Clinical Center, University of Debrecen, Debrecen, Hungary.
  • Csiba L; Department of Neurology, Clinical Center, University of Debrecen, Debrecen, Hungary.
J Am Soc Hypertens ; 8(8): 550-60, 2014 Aug.
Article en En | MEDLINE | ID: mdl-25151317
Hypertension and dyslipidemia belong to the most prevalent modifiable risk factors for cerebrovascular and cardiovascular diseases. Hereby, we aimed to examine the combined effects of newly diagnosed hypertension and hyperlipidemia on the characteristics of the arterial wall and on cognitive function. We examined 72 hypertensive and 85 apparently healthy individuals. Based on serum lipid levels, four subgroups were created ranging from normotensive-normolipidemic to hypertensive-hyperlipidemic subjects. Carotid intima-media thickness (IMT), arterial stiffness, and cognitive function were assessed. IMT of controls was the lowest, whereas that of patients with both risk factors the highest. Stiffness parameters increased when both risk factors were present, whereas subjects with only one risk factor exhibited intermediate values. Hypertensive patients performed worse when memory, attention, reaction time, and trait anxiety were assessed. Significant worsening of IMT, arterial stiffness, and sum of neuropsychological scores was observed along with increasing mean arterial pressure. Generally, hyperlipidemia combining with hypertension resulted in further worsening of all examined parameters. Subclinical changes of the vascular wall and cognitive performance are already present in recently diagnosed hypertensive patients. Combination of hyperlipidemia and hypertension results in more severe impairments, therefore, early and intensive treatment may be crucial to prevent further deterioration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Arterias Carótidas / Cognición / Rigidez Vascular / Hipertensión / LDL-Colesterol Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Soc Hypertens Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Arterias Carótidas / Cognición / Rigidez Vascular / Hipertensión / LDL-Colesterol Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Soc Hypertens Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos