Inhibition of MMP-2 expression with siRNA increases baseline cardiomyocyte contractility and protects against simulated ischemic reperfusion injury.

Lin, Han-Bin; Cadete, Virgilio J J; Sra, Bikramjit; Sawicka, Jolanta; Chen, Zhicheng; Bekar, Lane K; Cayabyab, Francisco; Sawicki, Grzegorz

Lin, Han-Bin; Cadete, Virgilio J J; Sra, Bikramjit; Sawicka, Jolanta; Chen, Zhicheng; Bekar, Lane K; Cayabyab, Francisco; Sawicki, Grzegorz.

Afiliación

Lin HB; Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
Cadete VJ; Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5 ; Faculté de Pharmacie, Université de Montréal, Montréal, QC, Canada H3T 1J4.
Sra B; Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
Sawicka J; Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
Chen Z; Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.
Bekar LK; Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5.
Cayabyab F; Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada S7N 5E5.
Sawicki G; Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5 ; Department of Clinical Chemistry, Medical University of Wroclaw, 50-556 Wroclaw, Poland.

Biomed Res Int ; 2014: 810371, 2014.

Article en En | MEDLINE | ID: mdl-25147815

Asunto(s)

Metaloproteinasa 2 de la Matriz/metabolismo; Contracción Muscular/fisiología; Daño por Reperfusión Miocárdica/metabolismo; Miocitos Cardíacos/metabolismo; ARN Interferente Pequeño/metabolismo; Animales; Miosinas Cardíacas/metabolismo; Masculino; Cadenas Ligeras de Miosina/metabolismo; Sustancias Protectoras/metabolismo; Ratas; Ratas Sprague-Dawley

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño por Reperfusión Miocárdica / Metaloproteinasa 2 de la Matriz / Miocitos Cardíacos / ARN Interferente Pequeño / Contracción Muscular Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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