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Clinical and molecular analyses of sporadic acute hepatitis A and E and the specific viral genotypes isolated in Iwate and three neighboring prefectures in the northern part of Honshu, Japan, between 2004 and 2013.
Suzuki, Kazuyuki; Kataoka, Kojiro; Miyamoto, Yasuhiro; Miyasaka, Akio; Kumagai, Ichiro; Takikawa, Yasuhiro; Takahashi, Masaharu; Okamoto, Hiroaki.
Afiliación
  • Suzuki K; Department of Nutritional Science, Morioka University, Morioka, Japan.
  • Kataoka K; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
  • Miyamoto Y; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
  • Miyasaka A; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
  • Kumagai I; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
  • Takikawa Y; Department of Internal Medicine, Morioka City Hospital, Morioka, Japan.
  • Takahashi M; Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
  • Okamoto H; Division of Virology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke, Japan.
Hepatol Res ; 45(7): 714-727, 2015 Jul.
Article en En | MEDLINE | ID: mdl-25146162
AIM: To examine the prevalence and characteristics of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections in the northern part of Honshu, Japan, during the last decade. METHODS: Using the registration system of a prospective cohort study for acute liver injury (ALI) in Iwate and three neighboring prefectures, we examined the prevalence of sporadic acute hepatitis (AH) with HAV (AH-A) and HEV (AH-E) and the distribution of viral genotypes in 487 patients diagnosed with ALI between 2004 and 2013. RESULTS: Among all 487 patients, 135 (28%) had ALI with viral infection. In the cases with viral ALI, the prevalence of hepatitis B virus-related AH was highest (55.6%). AH-E was seen in 23 patients (17.0%) and its prevalence was higher than that of AH-A (10 patients, 7.4%). There were no appreciable differences in the prevalence of AH-A and AH-E between 2004-2008 and 2009-2013. However, subgenotype IIIA HAV homologous to Korean strains has recently emerged, and the number of AH-E cases seems to be increasing. HEV genotype 3 was predominant throughout the observation period, but HEV genotype 4 was found in three patients after 2010. The transmission routes of HAV and HEV infections were unknown in approximately 60% of the patients. CONCLUSION: In the northern part of Honshu, Japan, HEV has been more frequently implicated in the development of AH than HAV, and HEV genotype 4 has been recently increasing. To provide an effective prophylactic management for HAV and HEV infections, further clarification of the transmission routes is needed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Hepatol Res Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Hepatol Res Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos