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Prediction of survival for patients with advanced colorectal cancer using (1) H High-resolution magic angle spinning nuclear MR spectroscopy.
Pacholczyk-Sienicka, Barbara; Fabianska, Anna; Pasz-Walczak, Grazyna; Kordek, Radzislaw; Jankowski, Stefan.
Afiliación
  • Pacholczyk-Sienicka B; Institute of Organic Chemistry, Faculty of Chemistry, Lodz, Lodz University of Technology, Poland.
  • Fabianska A; Institute of Organic Chemistry, Faculty of Chemistry, Lodz, Lodz University of Technology, Poland.
  • Pasz-Walczak G; Department of Pathology, Chair of Oncology, Lodz, Medical University of Lodz, Poland.
  • Kordek R; Department of Pathology, Chair of Oncology, Lodz, Medical University of Lodz, Poland.
  • Jankowski S; Institute of Organic Chemistry, Faculty of Chemistry, Lodz, Lodz University of Technology, Poland.
J Magn Reson Imaging ; 41(6): 1669-74, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25146159
PURPOSE: To evaluate whether the metabolic profiles of colorectal cancer specimens can be used for prediction of survival. MATERIALS AND METHODS: The metabolic profiles of colorectal cancer tissues were determined using the high-resolution magic angle spinning (HR MAS) nuclear magnetic resonance (NMR) technique (16.4 T). HR MAS analysis was performed for 52 tissues taken from patients classified as survivors and nonsurvivors (30). Quantitative analysis was performed for each spectrum. Receiver operating characteristic (ROC) curves were used to evaluate the potential to predict patient survival over 5.5 years. RESULTS: Analysis of (1) H NMR spectra led to the identification and quantitative analysis of 30 metabolites. A significant increase in the Tau/Gly and Tau/MI ratios were associated with long-term survival (P = 0.004 and P = 0.003, respectively). ROC analysis indicated that the Tau/MI ratio had the best predictive value for survival (sensitivity 64.7% and specificity 100%). Good predictive value of survival was found for Tau/Gly ratio (sensitivity 63.6% and specificity 96.3%). Moreover, the Glu/Gln metabolic ratio with a cutoff level of 1.74 was predictive of survival with a sensitivity of 83.3% and a specificity of 85.7%. CONCLUSION: Our results indicate that HR MAS spectroscopy is potentially useful for survival prediction in advanced colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectroscopía de Resonancia Magnética / Neoplasias Colorrectales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectroscopía de Resonancia Magnética / Neoplasias Colorrectales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Magn Reson Imaging Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2015 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos