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Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.
Quilter, Claire R; Cooper, Wendy N; Cliffe, Kerry M; Skinner, Benjamin M; Prentice, Philippa M; Nelson, LaTasha; Bauer, Julien; Ong, Ken K; Constância, Miguel; Lowe, William L; Affara, Nabeel A; Dunger, David B.
Afiliación
  • Quilter CR; Mammalian Molecular Genetics Group, Department of Pathology, crq20@cam.ac.uk.
  • Cooper WN; Metabolic Research Laboratories, Medical Research Council (MRC) Metabolic Diseases Unit, Department of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, Centre for Trophoblast Research, and.
  • Cliffe KM; Mammalian Molecular Genetics Group, Department of Pathology.
  • Skinner BM; Mammalian Molecular Genetics Group, Department of Pathology.
  • Prentice PM; National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Department of Paediatrics, University of Cambridge, Cambridge, UK; and.
  • Nelson L; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine Chicago, Chicago, Illinois, USA.
  • Bauer J; Mammalian Molecular Genetics Group, Department of Pathology.
  • Ong KK; National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Department of Paediatrics, University of Cambridge, Cambridge, UK; and.
  • Constância M; Metabolic Research Laboratories, Medical Research Council (MRC) Metabolic Diseases Unit, Department of Obstetrics and Gynaecology, National Institute for Health Research Cambridge Biomedical Research Centre, Centre for Trophoblast Research, and.
  • Lowe WL; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine Chicago, Chicago, Illinois, USA.
  • Affara NA; Mammalian Molecular Genetics Group, Department of Pathology.
  • Dunger DB; National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Department of Paediatrics, University of Cambridge, Cambridge, UK; and.
FASEB J ; 28(11): 4868-79, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25145626
Size at birth, postnatal weight gain, and adult risk for type 2 diabetes may reflect environmental exposures during developmental plasticity and may be mediated by epigenetics. Both low birth weight (BW), as a marker of fetal growth restraint, and high birth weight (BW), especially after gestational diabetes mellitus (GDM), have been linked to increased risk of adult type 2 diabetes. We assessed DNA methylation patterns using a bead chip in cord blood samples from infants of mothers with GDM (group 1) and infants with prenatal growth restraint indicated by rapid postnatal catch-up growth (group 2), compared with infants with normal postnatal growth (group 3). Seventy-five CpG loci were differentially methylated in groups 1 and 2 compared with the controls (group 3), representing 72 genes, many relevant to growth and diabetes. In replication studies using similar methodology, many of these differentially methylated regions were associated with levels of maternal glucose exposure below that defined by GDM [the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study] or were identified as changes observed after randomized periconceptional nutritional supplementation in a Gambian cohort characterized by maternal deprivation. These studies provide support for the concept that similar epigenetic modifications may underpin different prenatal exposures and potentially increase long-term risk for diseases such as type 2 diabetes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / Aumento de Peso / Diabetes Gestacional / Metilación de ADN / Desarrollo Fetal / Diabetes Mellitus Tipo 2 Tipo de estudio: Clinical_trials / Etiology_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peso al Nacer / Aumento de Peso / Diabetes Gestacional / Metilación de ADN / Desarrollo Fetal / Diabetes Mellitus Tipo 2 Tipo de estudio: Clinical_trials / Etiology_studies Límite: Adult / Female / Humans / Male / Pregnancy Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos