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Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.
Tordjman, Sylvie; Somogyi, Eszter; Coulon, Nathalie; Kermarrec, Solenn; Cohen, David; Bronsard, Guillaume; Bonnot, Olivier; Weismann-Arcache, Catherine; Botbol, Michel; Lauth, Bertrand; Ginchat, Vincent; Roubertoux, Pierre; Barburoth, Marianne; Kovess, Viviane; Geoffray, Marie-Maude; Xavier, Jean.
Afiliación
  • Tordjman S; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France ; Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Rennes 1, Centre Hospitalier Guillaume Régnier , Rennes , France.
  • Somogyi E; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
  • Coulon N; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
  • Kermarrec S; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France ; Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Rennes 1, Centre Hospitalier Guillaume Régnier , Rennes , France.
  • Cohen D; Department of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, University Pierre and Marie Curie , Paris , France.
  • Bronsard G; Laboratoire de Santé Publique (EA3279), School of Medicine of La Timone , Marseille , France.
  • Bonnot O; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
  • Weismann-Arcache C; Laboratoire Psychologie et Neurosciences de la Cognition et de l'Affectivité, Université de Rouen , Mont Saint Aignan , France.
  • Botbol M; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France ; Service Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Bretagne Occidentale, CHU de Brest , Brest , France.
  • Lauth B; Department of Child and Adolescent Psychiatry, Landspitali University Hospital, University of Iceland , Reykjavik , Iceland.
  • Ginchat V; Department of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, University Pierre and Marie Curie , Paris , France.
  • Roubertoux P; Laboratoire de Génétique Médicale, Génomique Fonctionnelle, INSERM U 910, Université d'Aix-Marseille 2 , Marseille , France.
  • Barburoth M; Laboratoire Psychologie de la Perception, Université Paris Descartes, CNRS UMR 8158 , Paris , France.
  • Kovess V; Department of Epidemiology and Biostatistics, EHESP School for Public Health, EA 4057 University Paris Descartes , Paris , France.
  • Geoffray MM; Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent Hospitalier Le Vinatier , Bron , France.
  • Xavier J; Department of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, University Pierre and Marie Curie , Paris , France.
Front Psychiatry ; 5: 53, 2014.
Article en En | MEDLINE | ID: mdl-25136320
Several studies support currently the hypothesis that autism etiology is based on a polygenic and epistatic model. However, despite advances in epidemiological, molecular and clinical genetics, the genetic risk factors remain difficult to identify, with the exception of a few chromosomal disorders and several single gene disorders associated with an increased risk for autism. Furthermore, several studies suggest a role of environmental factors in autism spectrum disorders (ASD). First, arguments for a genetic contribution to autism, based on updated family and twin studies, are examined. Second, a review of possible prenatal, perinatal, and postnatal environmental risk factors for ASD are presented. Then, the hypotheses are discussed concerning the underlying mechanisms related to a role of environmental factors in the development of ASD in association with genetic factors. In particular, epigenetics as a candidate biological mechanism for gene × environment interactions is considered and the possible role of epigenetic mechanisms reported in genetic disorders associated with ASD is discussed. Furthermore, the example of in utero exposure to valproate provides a good illustration of epigenetic mechanisms involved in ASD and innovative therapeutic strategies. Epigenetic remodeling by environmental factors opens new perspectives for a better understanding, prevention, and early therapeutic intervention of ASD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Psychiatry Año: 2014 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Psychiatry Año: 2014 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza