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[Safety and effectiveness of tumor-ablative chemotherapy combined with low intensity modified conditioning regimen for 30 patients with hematologic malignancies receiving allogeneic hematopoietic stem cell transplantation].
Luo, Rong-Mu; Da, Wan-ming; Hu, Bo; Si, Ying-Jian; Zhang, Xiao-Mei; Du, Zhen-Lan; Liu, Quan-Hua; Wang, Ya; Yue, Yan; Chen, Wei.
Afiliación
  • Luo RM; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Da WM; Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China. E-mail: Dwanming@hotmail.com.
  • Hu B; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Si YJ; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Zhang XM; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Du ZL; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Liu QH; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Wang Y; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Yue Y; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
  • Chen W; Department of Cell therapy, The General Hospital of Beijing Military Command, Beijing 100700, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 22(4): 1047-52, 2014 Aug.
Article en Zh | MEDLINE | ID: mdl-25130826
This study was aimed to investigate the safety and effectiveness of tumor-ablative Chemotherapy combined with low intensity conditioning regiment BUCy/TBICy for patients with hematologic malignancies receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 30 patients with hematologic malignancies received above-mentioned therapeutic method from January 2012 to January 2013 was analyzed retrospectively, and the engraftment, GVHD, infection, conditioning-related toxicity, relapse and survival rates were evaluated. All the patients signed the informed consent before transplantation. The median follow-up duration was 20.5 (16.3-27.3) months. The results indicated that all the patients had been engrafted successfully. One year overall survival (OS) and disease-free survival (DFS) rates were 93.3% and 83.3% respectively. No conditioning-related toxicity occurred. The incidences of II-IV grade aGVHD was 37.9%, among which incidence of III-IV grade aGVHD was 3.4%; incidence of extensive cGVHD was 13.8%. So far, 1 case relapsed, 1 case displayed graft rejection, and poor function of graft occurred in 1 case, death occurred in 2 cases(6.7%). It is concluded that tumor-ablative chemotherapy combined with low intensity-modified BUCy/TBICy is safe and effective in allogeneic hematopoietic stem cell transplantation for hematologic malignancies, and it is useful to reduce relapse of hematologic malignancies after transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Acondicionamiento Pretrasplante Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Acondicionamiento Pretrasplante Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: China