Enzymatic tumour tissue digestion coupled to SPE-UPLC-Tandem Mass Spectrometry as a tool to explore paclitaxel tumour penetration.

Colin, Pieter; De Smet, Lieselotte; De Bock, Lies; Goeteyn, Wim; Boussery, Koen; Vervaet, Chris; Van Bocxlaer, Jan

Colin, Pieter; De Smet, Lieselotte; De Bock, Lies; Goeteyn, Wim; Boussery, Koen; Vervaet, Chris; Van Bocxlaer, Jan.

Afiliación

Colin P; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium. Electronic address: Pieter.colin@ugent.be.
De Smet L; Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
De Bock L; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Goeteyn W; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Boussery K; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Vervaet C; Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.
Van Bocxlaer J; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

Talanta ; 129: 119-25, 2014 Nov.

Article en En | MEDLINE | ID: mdl-25127573

Asunto(s)

Química Farmacéutica/métodos; Neoplasias/tratamiento farmacológico; Paclitaxel/farmacocinética; Extracción en Fase Sólida/métodos; Espectrometría de Masas en Tándem/métodos; Animales; Antineoplásicos Fitogénicos/farmacocinética; Calibración; Bovinos; Cromatografía Liquida/métodos; Humanos; Microscopía Fluorescente/métodos; Músculos/metabolismo; Trasplante de Neoplasias; Ratas; Reproducibilidad de los Resultados

Palabras clave

Enzymatic digestion; Paclitaxel; Solid phase extraction; Tumour tissue; UPLCMS/MS

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Paclitaxel / Espectrometría de Masas en Tándem / Extracción en Fase Sólida / Neoplasias Tipo de estudio: Guideline / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Talanta Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos

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