Your browser doesn't support javascript.
loading
Involvement of IL-6 and IL-1 receptor antagonist on intellectual disability.
Aureli, A; Sebastiani, P; Del Beato, T; Marimpietri, A E; Graziani, A; Sechi, E; Di Loreto, S.
Afiliación
  • Aureli A; Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy.
  • Sebastiani P; Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy.
  • Del Beato T; Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy.
  • Marimpietri AE; Childhood and Adolescence Neuropsychiatric Clinic, University of L'Aquila, ASL n. 4, L'Aquila, Italy.
  • Graziani A; Childhood and Adolescence Neuropsychiatric Clinic, University of L'Aquila, ASL n. 4, L'Aquila, Italy.
  • Sechi E; Childhood and Adolescence Neuropsychiatric Clinic, University of L'Aquila, ASL n. 4, L'Aquila, Italy.
  • Di Loreto S; Institute of Translational Pharmacology (IFT) - National Council of Research (CNR), L'Aquila, Italy. Electronic address: silvia.diloreto@cnr.it.
Immunol Lett ; 162(1 Pt A): 124-31, 2014 Nov.
Article en En | MEDLINE | ID: mdl-25124963
Imbalances in the regulation of pro-inflammatory cytokines have been increasingly correlated with several neurodevelopmental disorders and their role in neuronal development is being investigated. To assess the possible influence of cytokines on the onset of intellectual disability (ID), we studied the polymorphisms of thirteen proinflammatory cytokine genes in 81 patients and 61 healthy controls. We demonstrated a significant association of interleukin-6 (IL-6) single-nucleotide polymorphism (SNP) (-174 G/C and nt565 G/A), and interleukin-1 receptor antagonist (IL-1RA) (Mspa-I 11100) SNP with ID. Moreover, the IL-6 SNPs is an unfavorable genetic predisposition for females. The evaluation of circulating levels of IL-6 and IL-1RA showed that the serum concentrations of IL-6 were significantly higher in ID patients than in controls. These data suggest that functional cytokine gene polymorphisms may influence the development of ID.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Interleucina-6 / Predisposición Genética a la Enfermedad / Proteína Antagonista del Receptor de Interleucina 1 / Discapacidad Intelectual Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Immunol Lett Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Interleucina-6 / Predisposición Genética a la Enfermedad / Proteína Antagonista del Receptor de Interleucina 1 / Discapacidad Intelectual Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Immunol Lett Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos