Your browser doesn't support javascript.
loading
Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway.
Ghebeh, H; Al-Khaldi, S; Olabi, S; Al-Dhfyan, A; Al-Mohanna, F; Barnawi, R; Tulbah, A; Al-Tweigeri, T; Ajarim, D; Al-Alwan, M.
Afiliación
  • Ghebeh H; Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Al-Khaldi S; The Joint Center for Genomics Research, King Abdulaziz City for Sciences and Technology, Riyadh, Saudi Arabia.
  • Olabi S; Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Al-Dhfyan A; Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Al-Mohanna F; Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Barnawi R; Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Tulbah A; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Al-Tweigeri T; Department of Oncology, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Ajarim D; Department of Oncology, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
  • Al-Alwan M; Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Centre, MBC: 03-99, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
Br J Cancer ; 111(8): 1552-61, 2014 Oct 14.
Article en En | MEDLINE | ID: mdl-25117814
BACKGROUND: A major therapeutic challenge for breast cancer is the ability of cancer cells to evade killing of conventional chemotherapeutic agents. We have recently reported the actin-bundling protein (fascin) as a major regulator of breast cancer metastasis and survival. METHODS: Survival of breast cancer patients that received chemotherapy and xenograft tumour model was used to assess the effect of chemotherapy on fascin-positive and -negative breast cancer cells. Molecular and cellular assays were used to gain in-depth understanding of the relationship between fascin and chemoresistance. RESULTS: We showed a significant correlation between fascin expression and shorter survival in breast cancer patients who received chemotherapy. In xenograft experiments, fascin-positive cancer cells displayed significantly more resistance to chemotherapy-mediated apoptotic cell death than fascin-negative counterparts. This increased chemoresistance was at least partially mediated through PI3K/Akt signalling, and was paralleled by increased FAK phosphorylation, enhanced expression of the inhibitor of apoptosis proteins (XIAP and Livin) and suppression of the proapoptotic markers (caspase 9, caspase 3 and PARP). CONCLUSIONS: This is the first report to demonstrate fascin involvement in breast cancer chemotherapeutic resistance, supporting the development of fascin-targeting drugs for better treatment of chemoresistance breast cancer.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Portadoras / Resistencia a Antineoplásicos / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Proteínas de Microfilamentos Límite: Animals / Female / Humans Idioma: En Revista: Br J Cancer Año: 2014 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Proteínas Portadoras / Resistencia a Antineoplásicos / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Proteínas de Microfilamentos Límite: Animals / Female / Humans Idioma: En Revista: Br J Cancer Año: 2014 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido