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A novel chemically modified curcumin reduces severity of experimental periodontal disease in rats: initial observations.
Elburki, Muna S; Rossa, Carlos; Guimaraes, Morgana R; Goodenough, Mark; Lee, Hsi-Ming; Curylofo, Fabiana A; Zhang, Yu; Johnson, Francis; Golub, Lorne M.
Afiliación
  • Elburki MS; Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
  • Rossa C; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP, 14801-903 Araraquara, SP, Brazil.
  • Guimaraes MR; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP, 14801-903 Araraquara, SP, Brazil.
  • Goodenough M; Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
  • Lee HM; Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
  • Curylofo FA; Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP, 14801-903 Araraquara, SP, Brazil.
  • Zhang Y; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA.
  • Johnson F; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA.
  • Golub LM; Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Mediators Inflamm ; 2014: 959471, 2014.
Article en En | MEDLINE | ID: mdl-25104884
Tetracycline-based matrix metalloproteinase- (MMP-) inhibitors are currently approved for two inflammatory diseases, periodontitis and rosacea. The current study addresses the therapeutic potential of a novel pleiotropic MMP-inhibitor not based on an antibiotic. To induce experimental periodontitis, endotoxin (LPS) was repeatedly injected into the gingiva of rats on one side of the maxilla; the contralateral (control) side received saline injections. Two groups of rats were treated by daily oral intubation with a chemically modified curcumin, CMC 2.24, for two weeks; the control groups received vehicle alone. After sacrifice, gingiva, blood, and maxilla were collected, the jaws were defleshed, and periodontal (alveolar) bone loss was quantified morphometrically and by µ-CT scan. The gingivae were pooled per experimental group, extracted, and analyzed for MMPs (gelatin zymography; western blot) and for cytokines (e.g., IL-1ß; ELISA); serum and plasma samples were analyzed for cytokines and MMP-8. The LPS-induced pathologically excessive bone loss was reduced to normal levels based on either morphometric (P = 0.003) or µ-CT (P = 0.008) analysis. A similar response was seen for MMPs and cytokines in the gingiva and blood. This initial study, on a novel triketonic zinc-binding CMC, indicates potential efficacy on inflammatory mediators and alveolar bone loss in experimental periodontitis and warrants future therapeutic and pharmacokinetic investigations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Periodontales / Periodontitis / Curcumina / Inhibidores de la Metaloproteinasa de la Matriz Límite: Animals Idioma: En Revista: Mediators Inflamm Asunto de la revista: BIOQUIMICA / PATOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Periodontales / Periodontitis / Curcumina / Inhibidores de la Metaloproteinasa de la Matriz Límite: Animals Idioma: En Revista: Mediators Inflamm Asunto de la revista: BIOQUIMICA / PATOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos