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A possible case of cherubism in a 17th-century Korean mummy.
Hershkovitz, Israel; Spigelman, Mark; Sarig, Rachel; Lim, Do-Sun; Lee, In Sun; Oh, Chang Seok; May, Hila; Boaretto, Elisabetta; Kim, Yi-Suk; Lee, Soong Deok; Peled, Nathan; Kim, Myeung Ju; Toledano, Talya; Bar-Gal, Gila Kahila; Shin, Dong Hoon.
Afiliación
  • Hershkovitz I; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Spigelman M; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Sarig R; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Lim DS; Department of Dental Hygiene, Eulji University, Seongnam, Gyeonggi-do, Korea.
  • Lee IS; Department of Diagnostic Radiology, Seoul National University College of Medicine, Seoul, Korea.
  • Oh CS; Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea; Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • May H; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
  • Boaretto E; D-REAMS Radiocarbon Dating Laboratory, Weizmann Institute of Science, Rehovot, Israel.
  • Kim YS; Department of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.
  • Lee SD; Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea; Department of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.
  • Peled N; Department of Radiology, Carmel Medical Center, Haifa, Israel.
  • Kim MJ; Department of Anatomy, Dankook University College of Medicine, Yongin-si, Gyeonggi-do, Korea.
  • Toledano T; Department of Radiology, Maimonides Medical Center, Brooklyn, New York, United States of America.
  • Bar-Gal GK; Department of Virology, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
  • Shin DH; Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea; Institute of Forensic Medicine, Seoul National University College of Medicine, Seoul, Korea.
PLoS One ; 9(8): e102441, 2014.
Article en En | MEDLINE | ID: mdl-25093864
Cherubism is a benign fibro-osseous disease of childhood limited specifically to the maxilla and mandible. The progressive replacement of the jaw bones with expansile multilocular cystic lesions causes eventual prominence of the lower face, and hence the classic "cherubic" phenotype reflecting variable extents of jaw hypertrophy. Histologically, this condition has been characterized as replacement of the normal bone matrix with multicystic pockets of fibrous stroma and osteoclastic giant cells. Because of radiographic features common to both, primarily the presence of multiloculated lucencies with heterogeneous "ground-glass" sclerosis on CT imaging, cherubism was long mistaken for a craniofacial subtype of fibrous dysplasia. In 1999, however, the distinct genetic basis for cherubism was mapped to chromosome 4p16.3 and the SH-3 binding protein SH3BP2. But while there are already three suspected cases of fibrous dysplasia amongst archaeological populations, no definitive cases of cherubism have yet been reported in historical populations. In the current study we describe micro- and macro-structural changes in the face of a 17th century Joseon Dynasty Korean mummy which may coincide with the clinic-pathologic and radiologic features of cherubism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Querubismo / Momias Límite: Adolescent / Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Querubismo / Momias Límite: Adolescent / Adult / Female / Humans País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos