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Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.
Guo, Chuangxing; Hou, Xinjun; Dong, Liming; Marakovits, Joseph; Greasley, Samantha; Dagostino, Eleanor; Ferre, RoseAnn; Johnson, M Catherine; Humphries, Paul S; Li, Haitao; Paderes, Genevieve D; Piraino, Joseph; Kraynov, Eugenia; Murray, Brion W.
Afiliación
  • Guo C; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA. Electronic address: alexguo01@gmail.com.
  • Hou X; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Dong L; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Marakovits J; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Greasley S; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Dagostino E; Oncology Research Unit, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Ferre R; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Johnson MC; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Humphries PS; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Li H; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Paderes GD; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Piraino J; Oncology Research Unit, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Kraynov E; Pharmacokinetics and Drug Metabolism, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.
  • Murray BW; Oncology Research Unit, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA. Electronic address: brion.murray@pfizer.com.
Bioorg Med Chem Lett ; 24(17): 4187-91, 2014 Sep 01.
Article en En | MEDLINE | ID: mdl-25091930
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos / Bencimidazoles / Ácidos Carboxílicos / Isomerasa de Peptidilprolil / Inhibidores Enzimáticos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfatos / Bencimidazoles / Ácidos Carboxílicos / Isomerasa de Peptidilprolil / Inhibidores Enzimáticos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido