[Bone marrow mononuclear cells from murine tibia after the space flight on biosatellite "Bion-M1"].
Aviakosm Ekolog Med
; 48(2): 5-11, 2014.
Article
en Ru
| MEDLINE
| ID: mdl-25087405
Cellularity, viability and immunophenotype of mononuclear cells derived from the tibial marrow of C57bL/6 mice were measured after the 30-day "Bion-M1" space flight and subsequent 7-day recovery. Cell number in the flight group was significantly less than in the group of vivarium control. There was no difference in the parameter between the flight and control groups after the recovery. Viability of mononuclear cells was more than 95% in all examined groups. Flow cytometric analysis failed to show differences in bone marrow cell immunophenotype (CD45, CD34, CD90.1 (Thy1); however, the flight animals had more large-sized CD45+ mononuclears than the control groups of mice. These results indicate that spaceflight factors did not have significant damaging effects on the number or immunophenotype of murine bone marrow mononuclears. These observations are consistent with the previously made assumption of a moderate and reversible stress reaction of mammals to space flight.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vuelo Espacial
/
Tibia
/
Células de la Médula Ósea
/
Leucocitos Mononucleares
Límite:
Animals
Idioma:
Ru
Revista:
Aviakosm Ekolog Med
Asunto de la revista:
MEDICINA AEROESPACIAL
/
SAUDE AMBIENTAL
Año:
2014
Tipo del documento:
Article
Pais de publicación:
Rusia