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A human fatty acid synthase inhibitor binds ß-ketoacyl reductase in the keto-substrate site.
Hardwicke, Mary Ann; Rendina, Alan R; Williams, Shawn P; Moore, Michael L; Wang, Liping; Krueger, Julie A; Plant, Ramona N; Totoritis, Rachel D; Zhang, Guofeng; Briand, Jacques; Burkhart, William A; Brown, Kristin K; Parrish, Cynthia A.
Afiliación
  • Hardwicke MA; 1] Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA. [2].
  • Rendina AR; 1] Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA. [2].
  • Williams SP; 1] Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, North Carolina, USA. [2].
  • Moore ML; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Wang L; Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
  • Krueger JA; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Plant RN; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Totoritis RD; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Zhang G; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Briand J; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Burkhart WA; Platform Technology and Science, GlaxoSmithKline, Research Triangle Park, North Carolina, USA.
  • Brown KK; Platform Technology and Science, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Parrish CA; Oncology Research and Development, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
Nat Chem Biol ; 10(9): 774-9, 2014 Sep.
Article en En | MEDLINE | ID: mdl-25086508
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Triazoles / Inhibidores Enzimáticos / Ácido Graso Sintasas / 3-Oxoacil-(Proteína Transportadora de Acil) Reductasa Límite: Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Triazoles / Inhibidores Enzimáticos / Ácido Graso Sintasas / 3-Oxoacil-(Proteína Transportadora de Acil) Reductasa Límite: Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos