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Evaluation of two commercially available rapid diagnostic tests for Lyme borreliosis.
Smit, P W; Kurkela, S; Kuusi, M; Vapalahti, O.
Afiliación
  • Smit PW; European Program for Public Health Microbiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden. pieterwsmit@gmail.com.
  • Kurkela S; Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland. pieterwsmit@gmail.com.
  • Kuusi M; Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Vapalahti O; Helsinki University Central Hospital Laboratory, Helsinki, Finland.
Eur J Clin Microbiol Infect Dis ; 34(1): 109-113, 2015 Jan.
Article en En | MEDLINE | ID: mdl-25073771
The diagnosis of Lyme disease is very complicated and a single diagnostic method cannot exclude infection. We assessed the performance of two commercially available Borrelia burgdorferi rapid diagnostic tests (RDT) in comparison to multiple laboratory-based diagnostic assays using specimens with a gradually increasing probability of Borrelia infection. Based on 200 specimens, the analytical sensitivities for IgG and IgM were 18 and 23% for the Lyme RDT and 24 and 32% for the Borreliose Complete RDT. The sensitivity for detecting diagnosed Lyme borreliosis cases was low (26% Lyme RDT and 32% with the Borreliose Complete RDT respectively), whereas the specificity was good (85% Lyme RDT and 88% Borreliose Complete). Based on this evaluation, the performance of RDTs in detecting Lyme borreliosis appeared to be below that of laboratory-based diagnostics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Lyme / Borrelia burgdorferi / Pruebas Diagnósticas de Rutina Tipo de estudio: Diagnostic_studies / Evaluation_studies Límite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Lyme / Borrelia burgdorferi / Pruebas Diagnósticas de Rutina Tipo de estudio: Diagnostic_studies / Evaluation_studies Límite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Alemania