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Apoptosis of antigen-specific CTLs contributes to low immune response in gut-associated lymphoid tissue post vaccination.
Shimada, Masaru; Yoshizaki, Shinji; Ichino, Motohide; Klinman, Dennis M; Okuda, Kenji.
Afiliación
  • Shimada M; Department of Molecular Biodefense Research, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan. Electronic address: mshimada@yokohama-cu.ac.jp.
  • Yoshizaki S; Department of Molecular Biodefense Research, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Ichino M; Department of Immunology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan.
  • Klinman DM; Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, United States.
  • Okuda K; Department of Molecular Biodefense Research, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan.
Vaccine ; 32(40): 5198-205, 2014 Sep 08.
Article en En | MEDLINE | ID: mdl-25066739
The gut-associated lymphoid tissue (GALT) represents a major reservoir of HIV in infected individuals. Vaccines can induce strong systemic immune responses but these have less impact on CD4 T cells activity and numbers in GALT. In this study, we vaccinated mice with an adenovirus vector that expressed the envelope gene from HIV and observed immune responses in the peripheral blood, spleen, liver, mesenteric lymph nodes, and Peyer's patches. We found that (1) the number of HIV-specific CD8 T cells was dramatically lower in GALT than in other tissues; (2) the programmed cell death protein-1 (PD-1) was expressed at high levels in HIV-specific CD8 T cells including memory T cells in GALT; and (3) high levels of HIV-specific CD8 T cell apoptosis were occurring in GALT. These results suggest that contributing to GALT becoming an HIV reservoir during infection is a combination of exhaustion and/or dysfunction of HIV-specific CTLs at that site. These results emphasize the importance of developing of an effective mucosal vaccine against HIV.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Infecciones por VIH / Apoptosis / Mucosa Intestinal / Tejido Linfoide Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Vaccine Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Infecciones por VIH / Apoptosis / Mucosa Intestinal / Tejido Linfoide Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Vaccine Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos