Extracorporeal complexation haemodialysis for the treatment of cadmium poisoning. II. In vivo mobilization and removal.
Pharmacol Toxicol
; 65(1): 13-6, 1989 Jul.
Article
en En
| MEDLINE
| ID: mdl-2506542
The purpose of this study was to apply our earlier in vitro findings for extracorporeal complexation combined with haemodialysis to in vivo conditions, for the enhancement of cadmium (Cd) removal from dogs. The results showed that ethylenediaminetetraacetic acid (EDTA), glutathione (GSH) and combination of the two agents (EDTA + GSH) facilitated efficient elimination of cadmium. GSH, EDTA and EDTA + GSH treatments brought about the clearance of 2.2, 14.7 and 18.2 micrograms Cd/kg body weight/hr haemodialysis, respectively. Treatment with EDTA + GSH brought about the most rapid extravascular redistribution of the metal.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Intoxicación por Cadmio
/
Quelantes
/
Diálisis Renal
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Toxicol
Asunto de la revista:
FARMACOLOGIA
/
TOXICOLOGIA
Año:
1989
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
Dinamarca