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ECM stiffness regulates glial migration in Drosophila and mammalian glioma models.
Kim, Su Na; Jeibmann, Astrid; Halama, Kathrin; Witte, Hanna Teresa; Wälte, Mike; Matzat, Till; Schillers, Hermann; Faber, Cornelius; Senner, Volker; Paulus, Werner; Klämbt, Christian.
Afiliación
  • Kim SN; Institute of Neurobiology, University of Münster, Münster 48149, Germany.
  • Jeibmann A; Institute of Neuropathology, University Hospital Münster, Münster 48149, Germany.
  • Halama K; Institute of Neuropathology, University Hospital Münster, Münster 48149, Germany.
  • Witte HT; Institute of Neurobiology, University of Münster, Münster 48149, Germany Institute of Neuropathology, University Hospital Münster, Münster 48149, Germany.
  • Wälte M; Institute of Physiology II, University Hospital Münster, Münster 48149, Germany.
  • Matzat T; Institute of Neurobiology, University of Münster, Münster 48149, Germany.
  • Schillers H; Institute of Physiology II, University Hospital Münster, Münster 48149, Germany.
  • Faber C; Department of Clinical Radiology, University Hospital Münster, Münster 48149, Germany.
  • Senner V; Institute of Neuropathology, University Hospital Münster, Münster 48149, Germany.
  • Paulus W; Institute of Neuropathology, University Hospital Münster, Münster 48149, Germany.
  • Klämbt C; Institute of Neurobiology, University of Münster, Münster 48149, Germany klaembt@uni-muenster.de.
Development ; 141(16): 3233-42, 2014 Aug.
Article en En | MEDLINE | ID: mdl-25063458
Cell migration is an important feature of glial cells. Here, we used the Drosophila eye disc to decipher the molecular network controlling glial migration. We stimulated glial motility by pan-glial PDGF receptor (PVR) activation and identified several genes acting downstream of PVR. Drosophila lox is a non-essential gene encoding a secreted protein that stiffens the extracellular matrix (ECM). Glial-specific knockdown of Integrin results in ECM softening. Moreover, we show that lox expression is regulated by Integrin signaling and vice versa, suggesting that a positive-feedback loop ensures a rigid ECM in the vicinity of migrating cells. The general implication of this model was tested in a mammalian glioma model, where a Lox-specific inhibitor unraveled a clear impact of ECM rigidity in glioma cell migration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuroglía / Proteínas de Drosophila / Drosophila melanogaster / Matriz Extracelular / Ojo Compuesto de los Artrópodos / Proteína-Lisina 6-Oxidasa Límite: Animals / Female / Humans Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuroglía / Proteínas de Drosophila / Drosophila melanogaster / Matriz Extracelular / Ojo Compuesto de los Artrópodos / Proteína-Lisina 6-Oxidasa Límite: Animals / Female / Humans Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido