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Day/night changes of thymus-deriving natural regulatory T cell development and function.
Kiernozek, Ewelina; Kowalik, Anna; Markowska, Magdalena; Kozlowska, Ewa; Drela, Nadzieja.
Afiliación
  • Kiernozek E; Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland. Electronic address: ekiernozek@biol.uw.edu.pl.
  • Kowalik A; Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
  • Markowska M; Department of Animal Physiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
  • Kozlowska E; Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
  • Drela N; Department of Immunology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland.
J Neuroimmunol ; 274(1-2): 102-10, 2014 Sep 15.
Article en En | MEDLINE | ID: mdl-25052584
Activity of the immune system shows day/night rhythmicity. Changes in the migration and biological activities of immune cells are strongly regulated by the HPA axis. Another mechanism governing the level of the immune response is based on the suppressive activity of natural regulatory T cells CD4+CD25+Foxp3+ (nTregs) which play a crucial role in the maintenance of self-tolerance and immune homeostasis. The aim of our study was to answer the question: are nTregs changing their development and suppressive activity according to day/night cycle? We demonstrated the effect of day time on nTreg distribution in the thymus and their suppressive potential to inhibit the proliferation of activated responder T cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timo / Ritmo Circadiano / Linfocitos T Reguladores Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timo / Ritmo Circadiano / Linfocitos T Reguladores Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos