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The association between family history of mental disorders and general cognitive ability.
McGrath, J J; Wray, N R; Pedersen, C B; Mortensen, P B; Greve, A N; Petersen, L.
Afiliación
  • McGrath JJ; 1] Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia [2] Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
  • Wray NR; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
  • Pedersen CB; 1] National Centre for Register-based Research, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [3] CIRRAU, Aarhus University, Aarhus, Demark.
  • Mortensen PB; 1] National Centre for Register-based Research, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [3] CIRRAU, Aarhus University, Aarhus, Demark.
  • Greve AN; 1] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark [2] Aarhus University Hospital, Risskov, Denmark.
  • Petersen L; 1] National Centre for Register-based Research, Aarhus University, Aarhus, Denmark [2] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Transl Psychiatry ; 4: e412, 2014 Jul 22.
Article en En | MEDLINE | ID: mdl-25050992
There is an emerging literature linking cognitive ability with a wide range of psychiatric disorders. These findings have led to the hypothesis that diminished 'cognitive reserve' is a causal risk factor for psychiatric disorders. However, it is also feasible that a family history of mental disorders may confound this relationship, by contributing to both a slight impairment in cognitive ability, and an increased risk of psychiatric disorder. On the basis of a large, population-based sample of young adult male conscripts (n=160 608), we examined whether the presence of a family history of a range of mental disorders was associated with cognitive ability, as tested by the Børge Priens Prøve. In those with no individual-level history of mental disorder, a family-level history of a mental disorder was associated with a slight reduction in cognitive ability. In general, this pattern was found regardless of the nature of the psychiatric disorder in the family. Our study suggests that shared familial factors may underpin both cognitive ability and the risk of a wide range of psychiatric disorders. Convergent evidence from epidemiology and genetics suggests that shared genetic factors underpin an unexpectedly diverse range of psychiatric disorders. On the basis of the findings of the current study, we speculate that these same shared genetic factors also contribute to general cognitive ability.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema de Registros / Inteligencia / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Transl Psychiatry Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema de Registros / Inteligencia / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Transl Psychiatry Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos