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Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells.
Beug, Shawn T; LaCasse, Eric C; Korneluk, Robert G.
Afiliación
  • Beug ST; Solange Gauthier Karsh Molecular Genetics Laboratory; Apoptosis Research Centre; Children's Hospital of Eastern Ontario Research Institute; Ottawa, Canada.
  • LaCasse EC; Solange Gauthier Karsh Molecular Genetics Laboratory; Apoptosis Research Centre; Children's Hospital of Eastern Ontario Research Institute; Ottawa, Canada.
  • Korneluk RG; Solange Gauthier Karsh Molecular Genetics Laboratory; Apoptosis Research Centre; Children's Hospital of Eastern Ontario Research Institute; Ottawa, Canada ; Department of Biochemistry, Microbiology and Immunology; University of Ottawa; Ottawa, Canada.
Oncoimmunology ; 3: e28541, 2014.
Article en En | MEDLINE | ID: mdl-25050221
A dual immunotherapy approach employing small-molecule inhibitors of apoptosis (IAP) protein antagonists in combination with innate immune stimuli has proven to be highly synergistic and effective in animal tumor models. This strategy overcomes many of the limitations of either single agent therapy and our results suggest that the combination could be easily and effectively translated to the clinic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncoimmunology Año: 2014 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncoimmunology Año: 2014 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos