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In vitro toxicity evaluation of Ti(4+)-stabilized γ-Bi2O3 sillenites.
Popescu, T; Lupu, A R; Feder, M; Tarabasanu-Mihaila, D; Teodorescu, V S; Vlaicu, A M; Diamandescu, L.
Afiliación
  • Popescu T; National Institute of Materials Physics, P.O. Box MG-7, Bucharest, Romania; University of Bucharest, Faculty of Physics, Bucharest, Romania. Electronic address: tr.popescu@gmail.com.
  • Lupu AR; Cantacuzino National Institute of Research and Development for Microbiology and Immunology, Bucharest, Romania.
  • Feder M; National Institute of Materials Physics, P.O. Box MG-7, Bucharest, Romania.
  • Tarabasanu-Mihaila D; National Institute of Materials Physics, P.O. Box MG-7, Bucharest, Romania.
  • Teodorescu VS; National Institute of Materials Physics, P.O. Box MG-7, Bucharest, Romania.
  • Vlaicu AM; National Institute of Materials Physics, P.O. Box MG-7, Bucharest, Romania.
  • Diamandescu L; National Institute of Materials Physics, P.O. Box MG-7, Bucharest, Romania.
Toxicol In Vitro ; 28(8): 1523-30, 2014 Dec.
Article en En | MEDLINE | ID: mdl-25025181
We report results regarding the in vitro toxicology of γ-Bi2O3 represented by its isomorphous phase Bi12TiO20 (γ-BTO). The γ-BTO microparticles were synthesized by two methods: coprecipitation from a bismuth nitrate-tetrabutyl titanate solution and solid state reaction of Bi2O3 and TiO2 oxides. The structural and morphological characteristics of the obtained materials were determined using X-ray diffraction (XRD), selected area electron diffraction (SAED), transmission (TEM) and scanning (SEM) electron microscopy. The elemental composition was investigated using energy dispersive spectrometry (EDS). The cytotoxicity and oxidative/nitrosative stress (intracellular reactive oxygen species (ROS) and nitric oxide (NO) release) induced by the studied microparticles in HepG2, SH-SY5Y and 3T3-L1 cell cultures were determined using the MTT, DCF-DA (2',7'-dichlorfluorescein-diacetate) and Griess methods respectively. Depending on the cell type and γ-BTO concentration, results showed only weak cytotoxic effects after 24h of γ-BTO exposure and cell proliferation effects for longer treatment times. Only reduced NO release increases (corresponding to high γ-BTO concentrations) were detected in case of SH-SY5Y and 3T3-L1 cells. The intracellular ROS production (higher for HepG2 cells) appeared inversely proportional to the γ-BTO concentration. The obtained results indicated a promising in vitro biocompatibility of γ-BTO and encourage further studies regarding its potential for biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Semiconductores / Titanio / Bismuto Límite: Animals / Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Semiconductores / Titanio / Bismuto Límite: Animals / Humans Idioma: En Revista: Toxicol In Vitro Asunto de la revista: TOXICOLOGIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido