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Prospective, randomized trial to evaluate efficacy of a thrombin-based hemostatic agent in total knee arthroplasty.
Suarez, Juan C; Slotkin, Eric M; Alvarez, Andres M; Szubski, Caleb R; Barsoum, Wael K; Patel, Preetesh D.
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  • Suarez JC; Cleveland Clinic Florida, Department of Orthopedic Surgery, 2950 Cleveland, Clinic Blvd, Weston, FL 33331.
  • Slotkin EM; Cleveland Clinic Florida, Department of Orthopedic Surgery, 2950 Cleveland, Clinic Blvd, Weston, FL 33331.
  • Alvarez AM; Cleveland Clinic Florida, Department of Orthopedic Surgery, 2950 Cleveland, Clinic Blvd, Weston, FL 33331.
  • Szubski CR; Cleveland Clinic, Department of Orthopedic Surgery, 9500 Euclid Avenue, Cleveland, OH 44195.
  • Barsoum WK; Cleveland Clinic, Department of Orthopedic Surgery, 9500 Euclid Avenue, Cleveland, OH 44195.
  • Patel PD; Cleveland Clinic Florida, Department of Orthopedic Surgery, 2950 Cleveland, Clinic Blvd, Weston, FL 33331.
J Arthroplasty ; 29(10): 1950-5, 2014 Oct.
Article en En | MEDLINE | ID: mdl-25015756
Total knee arthroplasty (TKA) can be associated with substantial blood loss, leading to increased morbidity and transfusion rates. The study objective was to evaluate routine use of a thrombin-based topical hemostatic matrix in reducing blood loss and transfusion requirements in primary TKA. 108 patients were enrolled in a prospective, randomized, single-center trial. Patients receiving the hemostatic agent demonstrated a lower mean calculated blood loss (1325.2±464.8mL vs. control, 1509.3±432.8mL; P=0.02), drain output (415.6±202.0mL vs. control, 579.9±306.7mL; P=0.008), and length of stay (3.3±0.8days vs. control, 3.7±1.1days; P=0.03), without a statistically significant difference in mean hemoglobin loss or transfusion requirements. The clinical utility of this hemostatic agent to reduce transfusions after uncomplicated, primary TKA continues to remain unclear.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemostáticos / Trombina / Pérdida de Sangre Quirúrgica / Hemorragia Posoperatoria / Artroplastia de Reemplazo de Rodilla / Esponja de Gelatina Absorbible Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Arthroplasty Asunto de la revista: ORTOPEDIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemostáticos / Trombina / Pérdida de Sangre Quirúrgica / Hemorragia Posoperatoria / Artroplastia de Reemplazo de Rodilla / Esponja de Gelatina Absorbible Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Arthroplasty Asunto de la revista: ORTOPEDIA Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos