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Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity.
Dung, Hoang Viet; Cuong, To Dao; Chinh, Nguyen Minh; Quyen, Do; Kim, Jeong Ah; Byeon, Jeong Su; Woo, Mi Hee; Choi, Jae Sui; Min, Byung Sun.
Afiliación
  • Dung HV; Centre of Pharmaceutical Research-Training, Vietnam Military Medical University, 160 Phung Hung, Hadong, Hanoi, Vietnam.
Arch Pharm Res ; 38(5): 677-82, 2015.
Article en En | MEDLINE | ID: mdl-25005067
A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 µM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Inhibidores de la Colinesterasa / Piper / Componentes Aéreos de las Plantas Idioma: En Revista: Arch Pharm Res Año: 2015 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Corea del Sur
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Inhibidores de la Colinesterasa / Piper / Componentes Aéreos de las Plantas Idioma: En Revista: Arch Pharm Res Año: 2015 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Corea del Sur