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Helicobacter pylori and t(11;18)(q21;q21) translocation in gastric malt lymphoma.
Lima, Karine Sampaio; Albuquerque, Walton; Arantes, Vitor Nunes; Drummond-Lage, Ana Paula; Coelho, Luiz Gonzaga Vaz.
Afiliación
  • Lima KS; Universidade Federal de Minas Gerais, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.
  • Albuquerque W; Universidade Federal de Minas Gerais, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.
  • Arantes VN; Universidade Federal de Minas Gerais, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.
  • Drummond-Lage AP; Faculdade de Ciências Médicas de Minas Gerais - FCMMG, Belo Horizonte, MG, Brasil.
  • Coelho LG; Universidade Federal de Minas Gerais, Instituto Alfa de Gastroenterologia, Belo Horizonte, MG, Brasil.
Arq Gastroenterol ; 51(2): 84-9, 2014.
Article en En | MEDLINE | ID: mdl-25003257
CONTEXT: Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is clearly associated with Helicobacter pylori gastritis and can be cured with anti- H pylori therapy alone. The presence of t(11;18)(q21;q21) translocation is thought to predict a lower response rate to anti- H pylori treatment. OBJECTIVES: To study the presence of t(11;18)(q21;q21) genetic translocation and its clinical impact in low-grade gastric MALT lymphoma Brazilian patients. METHODS: A consecutive series of eight patients with gastric MALT lymphoma were submitted to gastroscopy, endoscopic ultrasound, histopathological examination, H pylori search and RT-PCR-based methodology. All patients received anti-H pylori treatment. Eradicated patients were followed-up every 3-6 months for 2 years. RESULTS: Eight patients were studied. All patients had tumor involvement restricted to the mucosa or submucosa and seven patients had low-grade gastric MALT lymphoma. All infected patients achieved H pylori eradication. Histological tumor regression was observed in 5/7 (71%) of the low-grade gastric MALT lymphoma patients. The presence of t(11;18)(q21;q21) translocation was found in 4 (57%) of these patients; among them only two had histological tumor regression following H pylori eradication. CONCLUSIONS: RT-PCR is a feasible and efficient method to detect t(11;18)(q21;q21) translocation, being carried out in routine molecular biology laboratories. The early detection of such translocation can be very helpful for better targeting the therapy to be applied to gastric MALT lymphoma patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Translocación Genética / Helicobacter pylori / Infecciones por Helicobacter / Linfoma de Células B de la Zona Marginal Tipo de estudio: Prognostic_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Translocación Genética / Helicobacter pylori / Infecciones por Helicobacter / Linfoma de Células B de la Zona Marginal Tipo de estudio: Prognostic_studies / Screening_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arq Gastroenterol Año: 2014 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil