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Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Wilson, Barnabas; Lavanya, Y; Priyadarshini, S R B; Ramasamy, Muthu; Jenita, Josephine Leno.
Afiliación
  • Wilson B; Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India. Electronic address: antrilparavai@gmail.com.
  • Lavanya Y; Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
  • Priyadarshini SR; Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
  • Ramasamy M; Department of Bioengineering, School of Chemical & Biotechnology, SASTRA University, Thanjavur, Tamil Nadu 613401, India.
  • Jenita JL; Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumaraswamy Layout, Bangalore, Karnataka 560078, India.
Int J Pharm ; 473(1-2): 73-9, 2014 Oct 01.
Article en En | MEDLINE | ID: mdl-24999053
The study was aimed to prepare and evaluate gabapentin loaded albumin nanoparticles and to find out their effectiveness in treating epilepsy. Albumin nanoparticles of gabapentin were prepared by pH-coacervation method. The drug was administered into animals as free drug, gabapentin bound with nanoparticles, and gabapentin bound with nanoparticles coated with polysorbate 80. The polysorbate 80 coated nanoparticles increased the gabapentin concentration in the brain about 3 fold in comparison with the free drug. Moreover, the polysorbate 80 coated nanoparticles significantly reduced the duration of all phases of convulsion in both maximal electroshock induced and pentylenetetrazole induced convulsion models in comparison with free drug and drug bound with nanoparticle formulations, which indicates the ability of polysorbate 80 coated nanoparticles to enhance the gabapentin concentration in the brain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisorbatos / Albúmina Sérica Bovina / Portadores de Fármacos / Ácidos Ciclohexanocarboxílicos / Nanopartículas / Ácido gamma-Aminobutírico / Aminas / Anticonvulsivantes Idioma: En Revista: Int J Pharm Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisorbatos / Albúmina Sérica Bovina / Portadores de Fármacos / Ácidos Ciclohexanocarboxílicos / Nanopartículas / Ácido gamma-Aminobutírico / Aminas / Anticonvulsivantes Idioma: En Revista: Int J Pharm Año: 2014 Tipo del documento: Article Pais de publicación: Países Bajos