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Four GABAergic interneurons impose feeding restraint in Drosophila.
Pool, Allan-Hermann; Kvello, Pal; Mann, Kevin; Cheung, Samantha K; Gordon, Michael D; Wang, Liming; Scott, Kristin.
Afiliación
  • Pool AH; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
  • Kvello P; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
  • Mann K; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
  • Cheung SK; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
  • Gordon MD; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
  • Wang L; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA.
  • Scott K; Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, 16 Barker Hall, Berkeley, CA 94720, USA. Electronic address: kscott@berke
Neuron ; 83(1): 164-77, 2014 Jul 02.
Article en En | MEDLINE | ID: mdl-24991960
Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establish a central feeding threshold which is required to inhibit consumption. Inactivation of these cells results in indiscriminate and excessive intake of all compounds, independent of taste quality or nutritional state. Conversely, acute activation of these neurons suppresses consumption of water and nutrients. The output from these neurons is required to gate activity in motor neurons that control meal initiation and consumption. Thus, our study reveals a layer of inhibitory control in feeding circuits that is required to suppress a latent state of unrestricted and nonselective consumption.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Alimentaria / Neuronas GABAérgicas / Interneuronas Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Alimentaria / Neuronas GABAérgicas / Interneuronas Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos