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Role of cytokine gene polymorphisms in gastric cancer risk in Chile.
Gonzalez-Hormazabal, Patricio; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Escandar, Susana; Valladares, Hector; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, V Gonzalo; Rubio-Reyes, Cristian; Jara, Lilian; Berger, Zoltan.
Afiliación
  • Gonzalez-Hormazabal P; Human Genetics Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Santiago, Chile pgonzalez@med.uchile.cl.
  • Musleh M; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Bustamante M; Department of Surgery, School of Medicine at Eastern Campus, University of Chile, Santiago, Chile.
  • Stambuk J; Department of Surgery, San Juan de Dios Hospital, Santiago, Chile.
  • Escandar S; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile.
  • Valladares H; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Lanzarini E; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Chiong H; Department of Surgery, Barros Luco Hospital, Santiago, Chile.
  • Rojas J; Department of Surgery, University of Chile Clinical Hospital, Santiago, Chile.
  • Castro VG; Human Genetics Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Santiago, Chile.
  • Rubio-Reyes C; Human Genetics Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Santiago, Chile.
  • Jara L; Human Genetics Program, Institute of Biomedical Sciences, School of Medicine, University of Chile, Santiago, Chile.
  • Berger Z; Department of Gastroenterology, University of Chile Clinical Hospital, Santiago, Chile.
Anticancer Res ; 34(7): 3523-30, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24982364
AIM: To assess the role of pro- and anti-inflammatory polymorphisms in gastric cancer susceptibility. PATIENTS AND METHODS: We genotyped 12 polymorphisms in eight cytokine genes (Interleukin-1ß -IL1B-, IL8, IL17A, IL17F, IL32, tumor necrosis factor-α -TNF-, IL1RN, IL10) in a case-control study of 147 patients with gastric cancer and 172 controls. RESULTS: Single polymorphism analysis revealed an association between the IL10 -592C>A single nucleotide polymorphism and cases with moderately- or well-differentiated tumors [AA vs. GG, odds ratio (OR)=3.01; 95% confidence interval (CI)=1.08-8.50]. We further analyzed gene-gene interactions using a combined attribute network implemented in multifactor dimensionality reduction software. The analysis revealed an interaction between IL8 -251A>T and IL32 rs28372698 SNPs among cases with moderately- or well-differentiated tumors. Homozygosity for both IL8 -251T and IL32 T alleles increases the odds for developing gastric cancer up to 2.63-fold (OR=2.63; 95% CI=1.15-6.03). This association was higher compared to the homozygosity for the IL8-251 T allele alone (OR=1.11; 95% CI=0.51-2.43) or the IL32 T allele alone (OR=1.21; 95% CI=0.54-2.72). CONCLUSION: These findings suggest that IL10 -592C>A increases the odds for developing gastric cancer. An interaction between IL8 -251A>T and IL32 rs28372698 SNPs is also proposed.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Citocinas Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Chile Idioma: En Revista: Anticancer Res Año: 2014 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Grecia
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Citocinas Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Chile Idioma: En Revista: Anticancer Res Año: 2014 Tipo del documento: Article País de afiliación: Chile Pais de publicación: Grecia