TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease.

Liu, Yang-Lin; Reeves, Helen L; Burt, Alastair D; Tiniakos, Dina; McPherson, Stuart; Leathart, Julian B S; Allison, Michael E D; Alexander, Graeme J; Piguet, Anne-Christine; Anty, Rodolphe; Donaldson, Peter; Aithal, Guruprasad P; Francque, Sven; Van Gaal, Luc; Clement, Karine; Ratziu, Vlad; Dufour, Jean-Francois; Day, Christopher P; Daly, Ann K; Anstee, Quentin M

Liu, Yang-Lin; Reeves, Helen L; Burt, Alastair D; Tiniakos, Dina; McPherson, Stuart; Leathart, Julian B S; Allison, Michael E D; Alexander, Graeme J; Piguet, Anne-Christine; Anty, Rodolphe; Donaldson, Peter; Aithal, Guruprasad P; Francque, Sven; Van Gaal, Luc; Clement, Karine; Ratziu, Vlad; Dufour, Jean-Francois; Day, Christopher P; Daly, Ann K; Anstee, Quentin M.

Afiliación

Liu YL; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Reeves HL; Northern Institute for Cancer Research, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Burt AD; 1] Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK [2].
Tiniakos D; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
McPherson S; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Leathart JB; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Allison ME; Liver Unit, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Alexander GJ; Liver Unit, Department of Medicine, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Piguet AC; University Clinic of Visceral Surgery and Medicine, Inselspital Bern, 3010 Bern, Switzerland.
Anty R; 1] Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK [2] Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, Nice F-06204, Cedex 3, France.
Donaldson P; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Aithal GP; NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham NG7 2UH, UK.
Francque S; Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Antwerp, Belgium.
Van Gaal L; Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Wilrijkstraat 10, B-2650 Edegem, Antwerp, Belgium.
Clement K; Institute of Cardiometabolism and Nutrition, Pitié-Salpêtrière Hospital, 75013 Paris, France.
Ratziu V; Institute of Cardiometabolism and Nutrition, Pitié-Salpêtrière Hospital, 75013 Paris, France.
Dufour JF; University Clinic of Visceral Surgery and Medicine, Inselspital Bern, 3010 Bern, Switzerland.
Day CP; Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Daly AK; 1] Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK [2].
Anstee QM; 1] Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK [2].

Nat Commun ; 5: 4309, 2014 Jun 30.

Article en En | MEDLINE | ID: mdl-24978903

Asunto(s)

Cirrosis Hepática/genética; Proteínas de la Membrana/genética; Enfermedad del Hígado Graso no Alcohólico/genética; Polimorfismo de Nucleótido Simple; Adulto; Anciano; Alelos; Proteoglicanos Tipo Condroitín Sulfato/genética; Proteoglicanos Tipo Condroitín Sulfato/metabolismo; Estudios de Cohortes; Progresión de la Enfermedad; Femenino; Predisposición Genética a la Enfermedad; Genotipo; Heterocigoto; Humanos; Lectinas Tipo C/genética; Lectinas Tipo C/metabolismo; Hígado/metabolismo; Hígado/patología; Cirrosis Hepática/metabolismo; Cirrosis Hepática/patología; Masculino; Proteínas de la Membrana/metabolismo; Persona de Mediana Edad; Proteínas del Tejido Nervioso/genética; Proteínas del Tejido Nervioso/metabolismo; Neurocano; Enfermedad del Hígado Graso no Alcohólico/metabolismo; Enfermedad del Hígado Graso no Alcohólico/patología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Enfermedad del Hígado Graso no Alcohólico / Cirrosis Hepática / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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