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HP-1γ Controls High-Affinity Antibody Response to T-Dependent Antigens.
Ha, Ngoc; Pham, Duc-Hung; Shahsafaei, Aliakbar; Naruse, Chie; Asano, Masahide; Thai, To-Ha.
Afiliación
  • Ha N; Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School , Boston, MA , USA.
  • Pham DH; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven , Leuven , Belgium.
  • Shahsafaei A; Department of Pathology, Brigham and Women's Hospital , Boston, MA , USA.
  • Naruse C; Advanced Science Research Center, Kanazawa University , Kanazawa , Japan.
  • Asano M; Advanced Science Research Center, Kanazawa University , Kanazawa , Japan.
  • Thai TH; Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School , Boston, MA , USA.
Front Immunol ; 5: 271, 2014.
Article en En | MEDLINE | ID: mdl-24971082
In vitro observations suggest a role for the mouse heterochromatin protein 1γ (HP-1γ) in the immune system. However, it has not been shown if and how HP-1γ contributes to immunity in vivo. Here we show that in mice, HP-1γ positively regulates the germinal center reaction and high-affinity antibody response to thymus (T)-dependent antigens by limiting the size of CD8(+) regulatory T-cell (Treg) compartment without affecting progenitor B- or T-cell-development. Moreover, HP-1γ does not control cell proliferation or class switch recombination. Haploinsufficiency of cbx-3 (gene encoding HP-1γ) is sufficient to expand the CD8(+) Treg population and impair the immune response in mice despite the presence of wild-type HP-1α and HP-1ß. This is the first in vivo evidence demonstrating the non-redundant role of HP-1γ in immunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Immunol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Immunol Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza