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Heterogeneity and plasticity of epidermal stem cells.
Schepeler, Troels; Page, Mahalia E; Jensen, Kim B.
Afiliación
  • Schepeler T; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N DK-2200, Denmark.
  • Page ME; Wellcome Trust & Medical Research Council Cambridge Stem Cell Institute, Tennis Court Road, Cambridge CB2 1QR, UK.
  • Jensen KB; BRIC - Biotech Research and Innovation Centre, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N DK-2200, Denmark Wellcome Trust & Medical Research Council Cambridge Stem Cell Institute, Tennis Court Road, Cambridge CB2 1QR, UK kim.jensen@bric.ku.dk.
Development ; 141(13): 2559-67, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24961797
The epidermis is an integral part of our largest organ, the skin, and protects us against the hostile environment. It is a highly dynamic tissue that, during normal steady-state conditions, undergoes constant turnover. Multiple stem cell populations residing in autonomously maintained compartments facilitate this task. In this Review, we discuss stem cell behaviour during normal tissue homeostasis, regeneration and disease within the pilosebaceous unit, an integral structure of the epidermis that is responsible for hair growth and lubrication of the epithelium. We provide an up-to-date view of the pilosebaceous unit, encompassing the heterogeneity and plasticity of multiple discrete stem cell populations that are strongly influenced by external cues to maintain their identity and function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Células Madre / Transformación Celular Neoplásica / Folículo Piloso / Epidermis / Células Epidérmicas / Homeostasis Límite: Humans Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Células Madre / Transformación Celular Neoplásica / Folículo Piloso / Epidermis / Células Epidérmicas / Homeostasis Límite: Humans Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido