[Optimation the extracting technology of Angelica sinensis by central composite design and response surface methodology].
Zhong Yao Cai
; 36(11): 1853-7, 2013 Nov.
Article
en Zh
| MEDLINE
| ID: mdl-24956828
OBJECTIVE: To optimize the extracting technology from Angelica sinensis by central composite design-response surface methodology. METHODS: On the basis of the single factor,independent variables were ethanol concentrations, solvent ratio and ultrasonic time, while dependent variable was the OD value of extraction rates of ferulic acid and liqustilide. A two-order polynomial equation was fitted to estimate the relationship between independent and dependent variables. Response surface method was used to optimize the extracting process. RESULTS: The optimum extraction conditions for Angelica sinesis were obtained as follows: the extracting solvent was methanol concentrations of 70%, 30 fold solvent, extracting for once and for 40 minutes. The deviation between observed and predicted values was 1.23%. CONCLUSION: The result indicates that the central composite design and response surface methodology is simple, convenient and reliable for optimizing the extraction process of Angelica sinesis with higher precision.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
4-Butirolactona
/
Tecnología Farmacéutica
/
Ácidos Cumáricos
/
Angelica sinensis
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Zhong Yao Cai
Asunto de la revista:
TERAPIAS COMPLEMENTARES
Año:
2013
Tipo del documento:
Article
Pais de publicación:
China