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Non-alcoholic fatty liver disease, metabolic syndrome and patatin-like phospholipase domain-containing protein3 gene variants.
Del Ben, M; Polimeni, L; Brancorsini, M; Di Costanzo, A; D'Erasmo, L; Baratta, F; Loffredo, L; Pastori, D; Pignatelli, P; Violi, F; Arca, M; Angelico, F.
Afiliación
  • Del Ben M; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Polimeni L; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Brancorsini M; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Di Costanzo A; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • D'Erasmo L; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Baratta F; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Loffredo L; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Pastori D; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Pignatelli P; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Violi F; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Arca M; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Angelico F; Department of Public Health and Infectious Disease, Sapienza University, Rome, Italy. Electronic address: francesco.angelico@uniroma1.it.
Eur J Intern Med ; 25(6): 566-70, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24947770
BACKGROUND & AIMS: Non-alcoholic fatty liver disease was traditionally interpreted as a condition which may progress to liver-related complications. However, the increased mortality is primarily a result of cardiovascular diseases. It has been suggested that fatty liver can be considered as the hepatic consequence of the metabolic syndrome. The aim was to describe the different clinical presentations of non-alcoholic fatty liver disease on the basis of the patatin-like phospholipase domain-containing protein3 (PNPLA3) rs738409 gene variant. METHODS: Fatty liver was defined by ultrasonographic Hamaguchi's criteria in 211 consecutive subjects with non-alcoholic fatty liver disease. The rs738409 polymorphism was determined by TaqMan assays. Metabolic syndrome was defined according to ATPIII modified criteria. RESULTS: Prevalence of PNPLA3-148II, PNPLA3-148IM, and PNPLA3-148MM genotypes was 45.0%, 40.7%, and 14.3% respectively. Prevalence of metabolic syndrome progressively increased with the severity of liver steatosis (from 52.5% to 65.2%, and 82.3% respectively, p<0.01). The PNPLA3-148MM group had significantly lower mean serum triglycerides (p<0.001), Framingham cardiovascular risk score (p<0.01) and lower prevalence of metabolic syndrome (p<0.05) and its components. Age and HOMA-IR were positive independent predictors of metabolic syndrome, while a negative independent association was found between metabolic syndrome and the homozygotes PNPLA3 I148M variant. CONCLUSIONS: We suggest a lower prevalence of MetS and reduced cardiovascular risk in NAFLD patients with PNPLA3MM genotype.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico / Enfermedad del Hígado Graso no Alcohólico / Lipasa / Proteínas de la Membrana Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Metabólico / Enfermedad del Hígado Graso no Alcohólico / Lipasa / Proteínas de la Membrana Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2014 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos