Mitochondrial dysfunction has divergent, cell type-dependent effects on insulin action.

Martin, Sheree D; Morrison, Shona; Konstantopoulos, Nicky; McGee, Sean L

Martin, Sheree D; Morrison, Shona; Konstantopoulos, Nicky; McGee, Sean L.

Afiliación

Martin SD; Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia.
Morrison S; Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia.
Konstantopoulos N; Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia.
McGee SL; Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Geelong, Australia ; Cell Signalling and Metabolism Division, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

Mol Metab ; 3(4): 408-18, 2014 Jul.

Article en En | MEDLINE | ID: mdl-24944900

Palabras clave

AMPK, AMP-activated protein kinase; AS160, Akt substrate of 160 kDa; Adipocyte; BSA, bovine serum albumin; ECAR, extracellular acidification rate; FoxO1, forkhead box protein O1; G.O., glucose oxidase; GLUT4, facilitative glucose transporter isoform 4; GP, glucose production; HI-FBS, heat-inactivated foetal bovine serum; Hepatocyte; IRS1, insulin receptor substrate 1; Insulin action; LDH, lactate dehydrogenase; MMP, mitochondrial membrane potential; Mitochondria; MnTBAP, manganese (III) tetrakis (4-benzoic acid) porphyrin chloride; PI3K, phosphatidylinositol 3-kinase; ROS, reactive oxygen species; Reactive oxygen species; SOD, superoxide dismutase; T2D, type 2 diabetes; TNFα, tumour necrosis factor alpha

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Metab Año: 2014 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Alemania

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