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Rat-specific IgG and IgG4 antibodies associated with inhibition of IgE-allergen complex binding in laboratory animal workers.
Jones, M; Jeal, H; Schofield, S; Harris, J M; Shamji, M H; Francis, J N; Durham, S R; Cullinan, P.
Afiliación
  • Jones M; Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Jeal H; Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Schofield S; Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Harris JM; Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
  • Shamji MH; Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, part of the Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, London, UK.
  • Francis JN; Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, part of the Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, London, UK.
  • Durham SR; Department of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, part of the Medical Research Council and Asthma UK Centre for Allergic Mechanisms of Asthma, London, UK.
  • Cullinan P; Department of Occupational and Environmental Medicine, National Heart and Lung Institute, Imperial College London, London, UK.
Occup Environ Med ; 71(9): 619-23, 2014 Sep.
Article en En | MEDLINE | ID: mdl-24944289
OBJECTIVES: The relationship between exposure to rodent allergens and laboratory animal allergy is complex; at highest allergen exposures there is an attenuation of sensitisation and symptoms which are associated with increased levels of rat-specific immunoglobulin (Ig)G and IgG4 antibodies. We set out to examine whether the increased levels of rat-specific IgG and IgG4 antibodies that we have previously observed at high allergen exposure in our cohort of laboratory animal workers play a functional role through blockage of the binding of IgE-allergen complex binding to CD23 receptors on B cells. METHODS: Cross-sectional survey of laboratory animal workers (n=776) in six UK pharmaceutical companies were surveyed. IgE-allergen complex binding to B cells was measured in 703 (97.9%) eligible employees; their exposure was categorised by either job group or number of rats handled daily. RESULTS: We observed a significant decrease in IgE-allergen complex binding to B cells with increasing quartiles of both rat-specific IgG and IgG4 antibodies (p<0.001). IgE-allergen complex binding to B cells was lower in workers with high allergen exposure, and significantly so (p=0.033) in the subgroup with highest exposures but no work-related chest symptoms. CONCLUSIONS: These findings demonstrate a functional role for rat-specific IgG/G4 antibodies in laboratory animal workers, similar to that observed in patients treated with high dose immunotherapy who become clinically tolerant, suggesting a potential explanation for the attenuation of risk at highest allergen exposures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina E / Inmunoglobulina G / Alérgenos / Exposición Profesional / Técnicos de Animales / Hipersensibilidad / Enfermedades Profesionales Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Occup Environ Med Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina E / Inmunoglobulina G / Alérgenos / Exposición Profesional / Técnicos de Animales / Hipersensibilidad / Enfermedades Profesionales Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Occup Environ Med Asunto de la revista: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido