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Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia.
Villarreal, Mirta F; Drucaroff, Lucas J; Goldschmidt, Micaela G; de Achával, Delfina; Costanzo, Elsa Y; Castro, Mariana N; Ladrón-de-Guevara, M Soledad; Busatto Filho, Geraldo; Nemeroff, Charles B; Guinjoan, Salvador M.
Afiliación
  • Villarreal MF; National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina; Departament of Physics, School of Exact and Natural Sciences, University of Buenos Aires Ciudad Universitaria, Buenos Aires, Argentina; FLENI, Department of Neurology, Montañese
  • Drucaroff LJ; National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina; Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina; FLENI, Department
  • Goldschmidt MG; Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina; FLENI, Department of Neurology, Montañeses 2325, Buenos Aires C1428AQK, Argentina; FLENI, Department of Psychiatry, Montañeses 2325, Buenos
  • de Achával D; National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina; Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina; FLENI, Department
  • Costanzo EY; Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina; FLENI, Department of Psychiatry, Montañeses 2325, Buenos Aires C1428AQK, Argentina.
  • Castro MN; National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina; Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina; FLENI, Department
  • Ladrón-de-Guevara MS; National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina; FLENI, Department of Neurology, Montañeses 2325, Buenos Aires C1428AQK, Argentina; FLENI, Department of Psychiatry, Montañeses 2325, Buenos Aires C1428AQK, Argentina.
  • Busatto Filho G; Nucleo de Apoio à Pesquisa em Neurociência Aplicada, Universidade de São Paulo (NAPNA-USP), Brazil.
  • Nemeroff CB; Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, 1120 Northwest 14 St., Suite 1455, Miami, FL 33136, USA.
  • Guinjoan SM; National Council of Scientific and Technological Research (CONICET), Av. Rivadavia 1917, Buenos Aires C1033AAJ, Argentina; Department of Mental Health, FLENI Teaching Unit, School of Medicine, University of Buenos Aires, Montañeses 2325, 8th Floor, Buenos Aires C1428AQK, Argentina; Department of Neu
J Psychiatr Res ; 56: 120-9, 2014 Sep.
Article en En | MEDLINE | ID: mdl-24927685
Measures of social competence are closely related to actual community functioning in patients with schizophrenia. However, the neurobiological mechanisms underlying competence in schizophrenia are not fully understood. We hypothesized that social deficits in schizophrenia are explained, at least in part, by abnormally lateralized patterns of brain activation in response to tasks engaging social cognition, as compared to healthy individuals. We predicted such patterns would be partly heritable, and therefore affected in patients' nonpsychotic siblings as well. We used a functional magnetic resonance image paradigm to characterize brain activation induced by theory of mind tasks, and two tests of social competence, the Test of Adaptive Behavior in Schizophrenia (TABS), and the Social Skills Performance Assessment (SSPA) in siblings discordant for schizophrenia and comparable healthy controls (n = 14 per group). Healthy individuals showed the strongest correlation between social competence and activation of right hemisphere structures involved in social cognitive processing, whereas in patients, the correlation pattern was lateralized to left hemisphere areas. Unaffected siblings of patients exhibited a pattern intermediate between the other groups. These results support the hypothesis that schizophrenia may be characterized by an abnormal functioning of nondominant hemisphere structures involved in the processing of socially salient information.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Conducta Social / Encéfalo / Cognición / Hermanos / Habilidades Sociales Tipo de estudio: Observational_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male Idioma: En Revista: J Psychiatr Res Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Conducta Social / Encéfalo / Cognición / Hermanos / Habilidades Sociales Tipo de estudio: Observational_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male Idioma: En Revista: J Psychiatr Res Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido