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Effects of soyabean meal- or whey-based diets on lipid metabolism in weaned piglets.
Theodorou, G; Papadomichelakis, G; Tsiplakou, E; Lampidonis, A D; Chadio, S; Zervas, G; Politis, I.
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  • Theodorou G; Department of Animal Husbandry, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
  • Papadomichelakis G; Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
  • Tsiplakou E; Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
  • Lampidonis AD; Department of Animal Husbandry, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
  • Chadio S; Department of Anatomy and Physiology of Farm Animals, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
  • Zervas G; Department of Nutritional Physiology and Feeding, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
  • Politis I; Department of Animal Husbandry, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.
J Anim Physiol Anim Nutr (Berl) ; 99(1): 92-99, 2015 Feb.
Article en En | MEDLINE | ID: mdl-24924522
The present study aimed to test the hypothesis that dietary protein source influences lipid metabolism-related parameters weaned piglets. The effects of soyabean meal (SB) and whey proteins (WP) on gene expression of several genes involved in the lipogenic process in liver, visceral (VAT) and subcutaneous (SAT) adipose tissues, plasma insulin concentration and fatty acid (FA) profile were investigated in 18 weaned piglets. Weaned piglets were fed one of two diets containing either SB or WP as the main protein source. Following a 10-h fasting period, plasma insulin concentration and FA profile were assessed at 56 and 72 days of age, whereas gene expression in liver, VAT and SAT was assessed at 72 days of age. Plasma insulin concentration was not affected by diet, although it was 40% lower in SB fed pigs. The SB pigs had lower 14:0 (p < 0.01) and higher 18:3n-3 (p < 0.001) levels in plasma in comparison with WP pigs. However, these changes were attributed to background differences in the dietary FA profile and not to a direct protein source effect. Gene expression of sterol regulatory element-binding protein 1 (SREBP-1) in liver and VAT were lower (p < 0.01 and p < 0.05, respectively) in SB compared to WP fed piglets, but no differences occurred in SAT. No changes were observed in sterol regulatory element-binding protein 2, liver X receptor, peroxisome proliferator-activated receptors α and γ and plasminogen activator inhibitor 1 mRNA levels, either in liver or in adipose tissues. In conclusion, dietary protein source, accompanied likely by side alterations in the dietary composition, affects lipid metabolism in pigs through the downregulation of SREBP-1, which is a crucial determinant of lipogenic process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glycine max / Porcinos / Dieta / Metabolismo de los Lípidos / Alimentación Animal / Proteínas de la Leche Límite: Animals Idioma: En Revista: J Anim Physiol Anim Nutr (Berl) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA VETERINARIA Año: 2015 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glycine max / Porcinos / Dieta / Metabolismo de los Lípidos / Alimentación Animal / Proteínas de la Leche Límite: Animals Idioma: En Revista: J Anim Physiol Anim Nutr (Berl) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / MEDICINA VETERINARIA Año: 2015 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Alemania