Combined blockade of NMDA and AMPA receptors prevents acute kainate seizures and chronic kainate lethality in rats.
Bull Exp Biol Med
; 157(1): 15-7, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24906960
Single intramuscular injection of selective of NMDA receptor blocker memantine in the maximum dose of 20 mg/kg prevented the development of acute generalized tonic-clonic kainate seizures in 60% rats, but did not alleviate clonic kainate seizures and prevented chronic kainate lethality in only 30% rats. Intramuscular injection of NBQX, a selective blocker of AMPA receptors (10 mg/kg), produced more pronounced anticonvulsant and neuroprotective effects: it prevented generalized kainate seizures and chronic kainate lethality in 100 and 80% rats, respectively. However, even the high dose of NBQX prevented the clonic kainate seizures only in 30% rats. The intramuscular injection of novel agent IEM-2121 (0.03-1.00 mg/kg) known to block both AMPA and NMDA receptors, prevented the clonic kainate seizures only in 50-70%, although it precluded the chronic kainate lethality in 100%.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Convulsiones
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Adamantano
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Receptores de N-Metil-D-Aspartato
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Receptores AMPA
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Fármacos Neuroprotectores
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Aminas
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Anticonvulsivantes
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2014
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos