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False-positive Xpert® MTB/RIF assays in previously treated patients: need for caution in interpreting results.
Boyles, T H; Hughes, J; Cox, V; Burton, R; Meintjes, G; Mendelson, M.
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  • Boyles TH; <label>*</label>Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
  • Hughes J; <label><sup>†</sup></label>Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa.
  • Cox V; <label><sup>†</sup></label>Médecins Sans Frontières, Khayelitsha, Cape Town, South Africa.
  • Burton R; <label><sup>‡</sup></label>Khayelitsha District Hospital, Khayelitsha, Cape Town, South Africa.
  • Meintjes G; <label><sup>§</sup></label>Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Mendelson M; <label>*</label>Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Int J Tuberc Lung Dis ; 18(7): 876-8, 2014 Jul.
Article en En | MEDLINE | ID: mdl-24902569
Xpert(®) MTB/RIF is the initial diagnostic test of choice for tuberculosis (TB). It is not known if false-positive results are more common in previously treated patients. We report four patients with successful treatment for TB up to 5 years previously who presented with respiratory tract infection and were Xpert-positive, but had negative TB cultures and clinical improvement without anti-tuberculosis treatment. We hypothesise that the Xpert results were false-positive due to the presence of dead Mycobacterium tuberculosis bacilli in lungs and sputum. Further work is required to determine the specificity of Xpert in previously treated patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Tuberculosis / Técnicas de Amplificación de Ácido Nucleico / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies Límite: Female / Humans Idioma: En Revista: Int J Tuberc Lung Dis Año: 2014 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Francia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Tuberculosis / Técnicas de Amplificación de Ácido Nucleico / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies Límite: Female / Humans Idioma: En Revista: Int J Tuberc Lung Dis Año: 2014 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Francia