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A possible genetic influence in parenchyma and small airway changes in COPD: a pilot study of twins using HRCT.
Tarnoki, D L; Tarnoki, A D; Lazar, Zs; Korom, Cs; Berczi, V; Horvath, I; Karlinger, K.
Afiliación
  • Tarnoki DL; Semmelweis University Department of Radiology and Oncotherapy Ülloi út 78/a H-1082 Budapest Hungary.
  • Tarnoki AD; Semmelweis University Department of Radiology and Oncotherapy Ülloi út 78/a H-1082 Budapest Hungary.
  • Lazar Z; Semmelweis University Department of Pulmonology Budapest Hungary.
  • Korom C; Semmelweis University Department of Radiology and Oncotherapy Ülloi út 78/a H-1082 Budapest Hungary.
  • Berczi V; Semmelweis University Department of Radiology and Oncotherapy Ülloi út 78/a H-1082 Budapest Hungary.
  • Horvath I; Semmelweis University Department of Pulmonology Budapest Hungary.
Acta Physiol Hung ; 101(2): 167-75, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24901078
UNLABELLED: Genetic effects that contribute to the risk of developing chronic obstructive pulmonary disease (COPD) have been reported. Our purpose was to estimate the possible genetic influence on CT features related to COPD in twins. METHODS: Two COPD-discordant and one COPD-concordant monozygotic (MZ) twin pair, in addition to 2 control dizygotic (DZ) twin pairs underwent a low-dose high resolution computer tomography (HRCT) in inspiration and expiration (Philips Brilliance 16). RESULTS: Monozygotic twins were more similar in lung volume expiration and in air trapping score compared to dizygotics (382 cm(3) vs. 2303 cm(3) and 17.6% vs. 26.6%, respectively). In general, MZ twin pairs showed almost identical HRCT features independently of smoking attitude and COPD status. The dizygotic twin pairs showed larger differences in HRCT features compared to MZ twins. CONCLUSIONS: Lung parenchymal and small airway changes (lung density, presence of bronchial wall thickening, bronchiectasis and/or mucus plug formation, air trapping and emphysema score) seem to be genetically associated traits, independently of smoking/COPD history. A future study with a larger sample size should confirm our findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos Dicigóticos / Gemelos Monocigóticos / Enfermedad Pulmonar Obstructiva Crónica / Enfermedades en Gemelos / Tomografía Computarizada Multidetector / Pulmón Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Physiol Hung Año: 2014 Tipo del documento: Article Pais de publicación: Hungria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gemelos Dicigóticos / Gemelos Monocigóticos / Enfermedad Pulmonar Obstructiva Crónica / Enfermedades en Gemelos / Tomografía Computarizada Multidetector / Pulmón Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Physiol Hung Año: 2014 Tipo del documento: Article Pais de publicación: Hungria