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Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein.
Thompson, Christopher F; Ali, Amjad; Quraishi, Nazia; Lu, Zhijian; Hammond, Milton L; Sinclair, Peter J; Anderson, Matt S; Eveland, Suzanne S; Guo, Qiu; Hyland, Sheryl A; Milot, Denise P; Sparrow, Carl P; Wright, Samuel D.
Afiliación
  • Thompson CF; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Ali A; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Quraishi N; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Lu Z; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Hammond ML; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Sinclair PJ; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Anderson MS; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Eveland SS; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Guo Q; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Hyland SA; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Milot DP; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Sparrow CP; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
  • Wright SD; Departments of Medicinal Chemistry and Cardiovascular Diseases, Merck Research Laboratories , Rahway, New Jersey 07065, United States.
ACS Med Chem Lett ; 2(6): 424-7, 2011 Jun 09.
Article en En | MEDLINE | ID: mdl-24900324
Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. Inhibition of cholesteryl ester transfer protein (CETP) has been shown to elevate HDL-C levels in human subjects. This letter describes the discovery of a novel and potent (<100 nM IC50 for the inhibition of CE transfer) CETP inhibitor scaffold containing an oxazolidinone core.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2011 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos