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TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.
Shrestha, Roshan L; Tamura, Naoka; Fries, Anna; Levin, Nicolas; Clark, Joanna; Draviam, Viji M.
Afiliación
  • Shrestha RL; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Tamura N; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Fries A; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Levin N; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Clark J; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
  • Draviam VM; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK vmd20@cam.ac.uk.
Open Biol ; 4(6): 130108, 2014 Jun.
Article en En | MEDLINE | ID: mdl-24898139
Chromosomal instability can arise from defects in chromosome-microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. We demonstrate the aneugenic nature of chromosome-microtubule attachment defects in TAO1-depleted cells using an error-correction assay. Our model further strengthens the emerging paradigm that microtubule regulatory pathways are important for resolving erroneous kinetochore-microtubule attachments and maintaining the integrity of the genome, regardless of the spindle checkpoint status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas / Quinasas Quinasa Quinasa PAM / Inestabilidad Cromosómica Límite: Humans Idioma: En Revista: Open Biol Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cromosomas / Quinasas Quinasa Quinasa PAM / Inestabilidad Cromosómica Límite: Humans Idioma: En Revista: Open Biol Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido