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Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster.
Jeibmann, Astrid; Eikmeier, Kristin; Linge, Anna; Kool, Marcel; Koos, Björn; Schulz, Jacqueline; Albrecht, Stefanie; Bartelheim, Kerstin; Frühwald, Michael C; Pfister, Stefan M; Paulus, Werner; Hasselblatt, Martin.
Afiliación
  • Jeibmann A; 1] Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany [2].
  • Eikmeier K; 1] Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany [2].
  • Linge A; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany.
  • Kool M; Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  • Koos B; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Box 815, 75108 Uppsala, Sweden.
  • Schulz J; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany.
  • Albrecht S; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany.
  • Bartelheim K; Swabian Childrens' Cancer Center, Childrens' Hospital Augsburg and EU-RHAB Registry, Stenglinstr. 2, 86156 Augsburg, Germany.
  • Frühwald MC; Swabian Childrens' Cancer Center, Childrens' Hospital Augsburg and EU-RHAB Registry, Stenglinstr. 2, 86156 Augsburg, Germany.
  • Pfister SM; Division of Pediatric Neurooncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
  • Paulus W; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany.
  • Hasselblatt M; Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149 Münster, Germany.
Nat Commun ; 5: 4005, 2014 Jun 03.
Article en En | MEDLINE | ID: mdl-24892285
Atypical teratoid/rhabdoid tumours (AT/RT) are malignant brain tumours. Unlike most other human brain tumours, AT/RT are characterized by inactivation of one single gene, SMARCB1. SMARCB1 is a member of the evolutionarily conserved SWI/SNF chromatin remodelling complex, which has an important role in the control of cell differentiation and proliferation. Little is known, however, about the pathways involved in the oncogenic effects of SMARCB1 inactivation, which might also represent targets for treatment. Here we report a comprehensive genetic screen in the fruit fly that revealed several genes not yet associated with loss of snr1, the Drosophila homologue of SMARCB1. We confirm the functional role of identified genes (including merlin, kibra and expanded, known to regulate hippo signalling pathway activity) in human rhabdoid tumour cell lines and AT/RT tumour samples. These results demonstrate that fly models can be employed for the identification of clinically relevant pathways in human cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Teratoma / Factores de Transcripción / Neoplasias Encefálicas / Tumor Rabdoide / Proteínas de Drosophila Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Teratoma / Factores de Transcripción / Neoplasias Encefálicas / Tumor Rabdoide / Proteínas de Drosophila Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2014 Tipo del documento: Article Pais de publicación: Reino Unido