Shared genetic factors underlie chronic pain syndromes.

Vehof, Jelle; Zavos, Helena M S; Lachance, Genevieve; Hammond, Christopher J; Williams, Frances M K

Vehof, Jelle; Zavos, Helena M S; Lachance, Genevieve; Hammond, Christopher J; Williams, Frances M K.

Afiliación

Vehof J; Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK Department of Ophthalmology and Epidemiology, University Medical Center Groningen, Groningen, The Netherlands Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, UK Department of Ophthalmology, King's College London, St. Thomas' Hospital, London, UK Department of Rheumatology, King's College London, St. Thomas' Hospital, L

Pain ; 155(8): 1562-1568, 2014 Aug.

Article en En | MEDLINE | ID: mdl-24879916

RESUMEN

Chronic pain syndromes (CPS) are highly prevalent in the general population, and increasingly the evidence points to a common etiological pathway. Using a large cohort of twins (n=8564) characterized for chronic widespread musculoskeletal pain (CWP), chronic pelvic pain (PP), migraine (MIG), dry eye disease, and irritable bowel syndrome (IBS), we explored the underlying genetic and environmental factors contributing to CPS and the correlation between them. The sample was predominantly female (87.3%), with a mean age of 54.7 (±14.7) years. Prevalence of the different CPS ranged from 7.4% (PP) to 15.7% (MIG). For all CPS the within-twin correlation in monozygotic twin pairs was higher than in dizygotic pairs, suggesting a heritable component. Estimated heritability ranged from 19% (IBS) to 46% (PP). Except for MIG, we found significant pairwise phenotypic correlations between the CPS. The phenotypic correlation was highest between CWP and IBS (0.40; 95% confidence interval: 0.27 to 0.46). Excluding MIG from further analyses, cross-twin cross-trait correlations were higher in monozygotic compared with dizygotic twin pairs, suggestive of shared genetic factors between CWP, PP, IBS, and dry eye disease. Twin modeling analysis revealed the common pathway model as the model best explaining the observed pattern of correlation between the traits, with an estimated heritability of 66% of the underlying latent variable. These results are evidence of shared genetic factors in conditions manifesting chronic pain and justify the search for underlying genetic variants.

Asunto(s)

Dolor Crónico/genética; Enfermedades en Gemelos/genética; Síndromes de Ojo Seco/genética; Síndrome del Colon Irritable/genética; Trastornos Migrañosos/genética; Dolor Musculoesquelético/genética; Dolor Pélvico/genética; Adulto; Anciano; Dolor Crónico/epidemiología; Enfermedades en Gemelos/epidemiología; Síndromes de Ojo Seco/epidemiología; Femenino; Predisposición Genética a la Enfermedad; Humanos; Síndrome del Colon Irritable/epidemiología; Masculino; Persona de Mediana Edad; Trastornos Migrañosos/epidemiología; Dolor Musculoesquelético/epidemiología; Dolor Pélvico/epidemiología; Fenotipo; Prevalencia; Factores de Riesgo; Gemelos/genética

Palabras clave

Chronic pain syndrome; Chronic widespread pain; Dry eye disease; Environment; Functional somatic syndrome; Gene; Heritability; Irritable bowel syndrome; Migraine; Pain; Pelvic pain

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndromes de Ojo Seco / Dolor Pélvico / Síndrome del Colon Irritable / Enfermedades en Gemelos / Dolor Musculoesquelético / Dolor Crónico / Trastornos Migrañosos Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2014 Tipo del documento: Article Pais de publicación: Estados Unidos

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