RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNF&#945; in the microenvironment.

Yuan, Lingqing; Chan, Godfrey Chi Fung; Fung, Kwong Lam; Chim, Chor Sang

RANKL expression in myeloma cells is regulated by a network involving RANKL promoter methylation, DNMT1, microRNA and TNFα in the microenvironment.

Yuan, Lingqing; Chan, Godfrey Chi Fung; Fung, Kwong Lam; Chim, Chor Sang.

Afiliación

Yuan L; Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China; Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chan GC; Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China; Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Fung KL; Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China; Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Chim CS; Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China; Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address: jcschim@hku.hk.

Biochim Biophys Acta ; 1843(9): 1834-8, 2014 Sep.

Article en En | MEDLINE | ID: mdl-24875904

Asunto(s)

ADN (Citosina-5-)-Metiltransferasas/metabolismo; Metilación de ADN/genética; MicroARNs/metabolismo; Mieloma Múltiple/genética; Regiones Promotoras Genéticas; Ligando RANK/genética; Microambiente Tumoral/genética; Factor de Necrosis Tumoral alfa/metabolismo; Técnicas de Cocultivo; ADN (Citosina-5-)-Metiltransferasa 1; Regulación Neoplásica de la Expresión Génica; Redes Reguladoras de Genes; Humanos; Células Madre Mesenquimatosas/metabolismo; Células Madre Mesenquimatosas/patología; MicroARNs/genética; Ligando RANK/metabolismo

Palabras clave

DNA methylation; DNMT1; MicroRNA; Myeloma microenvironment; RANKL; TNFα

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regiones Promotoras Genéticas / Factor de Necrosis Tumoral alfa / Metilación de ADN / MicroARNs / ADN (Citosina-5-)-Metiltransferasas / Ligando RANK / Microambiente Tumoral / Mieloma Múltiple Límite: Humans Idioma: En Revista: Biochim Biophys Acta Año: 2014 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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